TRIM family proteins and their emerging roles in innate immunity
By K. Ozato, Dong-Mi Shin, Tsung-Hsien Chang, H. Morse. Nature reviews. Immunology, 2008
1,095 citations recorded by the source corpus.
The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to pathogens, and several are known to be required for the restriction of infection by lentiviruses. In this Review, we describe recent data that reveal broader antiviral and antimicrobial activities of TRIM proteins and discuss their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/ed1b291c6682acbc70311a49aec9f2565804addd
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Citations in the corpus
- TRIM proteins and cancer (2011, background): “8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes.”
- Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “In addition, tripartite motif (TRIM) proteins, containing an N-terminal RING domain with potential ubiquitin E3 ligase activity, represent a new class of antiviral molecules involved in innate immunity (Nisole et al., 2005; Ozato et al., 2008).”
- Interferon-Stimulated Genes: A Complex Web of Host Defenses (2014, background): “Together, these subdomains are responsible for conferring additional mechanisms of target specificity for protein-protein interaction (156).”