A study on the fate of curcumin in the rat.

By Bo Wahlström, G. Blennow. Acta Pharmacologica et Toxicologica, 2009

623 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/39ccb20af458ea19e6ada8b1a1a7158298002775

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Citations in the corpus

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment (2011, background): “75% of the dose being excreted in faeces and negligible amounts were detected in the urine [38].”
Curcumin: the story so far. (2005, neutral): “Studies of curcumin in animals have confirmed a lack of significant toxicity since an early report in which doses up to 5 g/kg were administered orally to Sprague–Dawley rats [16].”
The Chemistry of Curcumin: From Extraction to Therapeutic Agent (2014, background): “The metabolism of curcumin in rats and humans produces different products [49–53].”
Regulation of inflammation and redox signaling by dietary polyphenols. (2006, background): “Pharmacokinetic measurements have revealed that about 40– 85% of ingested curcumin is unaltered in the gastrointestinal tract, most of the absorbed flavonoid being metabolized in the intestinal mucosa and liver [11].”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, neutral): “In the first published study, a dose of 1 g/kg was administered orally to rats, resulting in (cid:2) 75% of the dose being excreted in the feces, and negligible amounts appearing in the urine (271).”
Multiple biological activities of curcumin: a short review. (2006, background): “…was shown that oral consumption of curcumin in rats resulted in approximately 75% being excreted in the feces and only traces appeared in the urine (Wahlstrom and Blennow, 1978), whereas intra-peritoneal (i.p) administration accounted for similar levels of fecal excretion of curcumin, with only…”
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. (2001, background): “4 179 (100); 165 (16); 193 (17); 373 (10) Hepatocyte metabolite 2 22.”
Curcumin as "Curecumin": from kitchen to clinic. (2008, background): “As several groups have shown, the liver appears to be the major organ responsible for metabolism of curcumin [150,156,157].”
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. (2001, background): “In rodents, curcumin undergoes avid metabolism by conjugation and reduction, and its disposition after oral dosing is characterized by poor systemic bioavailability (9, 17, 19, 20).”