The Chemistry of Curcumin: From Extraction to Therapeutic Agent

By K. Priyadarsini. Molecules, 2014

1,362 citations recorded by the source corpus.

Curcumin, a pigment from turmeric, is one of the very few promising natural products that has been extensively investigated by researchers from both the biological and chemical point of view. While there are several reviews on the biological and pharmacological effects of curcumin, chemistry reviews are comparatively scarcer. In this article, an overview of different aspects of the unique chemistry research on curcumin will be discussed. These include methods for the extraction from turmeric, laboratory synthesis methods, chemical and photochemical degradation and the chemistry behind its metabolism. Additionally other chemical reactions that have biological relevance like nucleophilic addition reactions, and metal chelation will be discussed. Recent advances in the preparation of new curcumin nanoconjugates with metal and metal oxide nanoparticles will also be mentioned. Directions for future investigations to be undertaken in the chemistry of curcumin have also been suggested.

Subfields: Molecular Medicine, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/2a64c59952b43e5928b926f3fdaf298c04d9a313

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. Raghavendhar R. Kotha
2. A. Mauri
3. P. Salgado
4. D. Kalman
5. Devanand L. Luthria
6. Y. S. Musso
7. S. Hewlings

In Pharmacology

1. Raghavendhar R. Kotha
2. A. Mauri
3. P. Salgado
4. D. Kalman
5. Devanand L. Luthria
6. Y. S. Musso
7. S. Hewlings

In Physiology

1. Raghavendhar R. Kotha
2. A. Mauri
3. P. Salgado
4. D. Kalman
5. Devanand L. Luthria
6. Y. S. Musso
7. S. Hewlings

Citations in the corpus

• Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects (2019, background): “CUR degradation occurs upon exposure to sunlight [50,55] which is commonly observed by quick removal of turmeric stains when exposed to sunlight.”
• Combination therapy in combating cancer (2017, background): “One such pharmaceutical agent is curcumin, the principal curcuminoid derived compound from turmeric (Curcuma longa) in the ginger family, Zingiberaceae [44].”
• Bioactivity of dietary polyphenols: The role of metabolites (2020, background): “The ketone form is metabolically targeted for reduction and conjugation: curcumin is more susceptible to degradation and reduction at the diketo moiety and conjugation is mediated by the hydroxyl groups (Priyadarsini 2014; Stani c 2017).”
• Smart edible films based on gelatin and curcumin (2017, background): “A more intense coloration in hydroalcoholic films can be due to curcumin's higher solubility in this medium than in water because of its hydrophobic nature (Priyadarsini, 2014).”
• Curcumin: A Review of Its’ Effects on Human Health (2017, background): “Turmeric is a rhizomatous herbaceous perennial plant (Curcuma longa) of the ginger family [1].”
• The Essential Medicinal Chemistry of Curcumin (2017, neutral): “33 Although the multicomponent nature of “ curcumin ” is well documented, that fact and/or the unambiguous assignment of speci fi c structures in a particular preparation is not always clear.”