Fcgamma receptors as regulators of immune responses.
By F. Nimmerjahn, J. Ravetch. Nature reviews. Immunology, 2008
1,436 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/39ca69eb557cf2b4ce5944b18067814b648c165c
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Citations in the corpus
- Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools (2020, background): “Antibody or small molecule-mediated blockage of FcRn can prevent IgG interaction with FcRn, which can decrease circulating IgG levels (Nimmerjahn and Ravetch 2008b).”
- Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose (2011, background): “Furthermore, posttranslational modifications, in particular glycosylation, of both antibodies and Fcγ receptors modulate the affinity of their interactions (1, 2).”
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma (2013, background): “In mice, ADCC is regulated predominantly by the low-affinity receptors FcRIII and FcRIV (Nimmerjahn et al., 2005; Nimmerjahn et al., 2010; Setiady et al., 2010), and to a lesser extent by the highaffinity FcRI (Fossati-Jimack et al., 2000; Tedder et al., 2006; Hamaguchi et al., 2006).”
- Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge (2009, background): “Binding of antigen-engaged IgGs to FcRs activates effector functions such as phagocytosis, endocytosis of IgG-opsonized particles, release of inflammatory cytokines and chemokines, and antibody-dependent cytoxicity (ADCC) of IgG-coated cells (1).”
- From Vaccines to Memory and Back (2010, unknown): “The B cell system is also under homeostatic control and there are mechanisms for regulating naïve and memory B cell numbers as well as total immunoglobulin levels in the serum (Nimmerjahn and Ravetch, 2008; Sanz et al., 2008).”
- Role of Bruton’s tyrosine kinase in B cells and malignancies (2018, background): “For example, the FcγRIIB is an inhibitory receptor that is exclusively expressed on B cells [60].”