Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

By Yajing Fu, Yuanxiong Cheng, Yuntao Wu. Virologica Sinica, 2020

716 citations recorded by the source corpus.

Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/505580e498e700c65cb6ea808aa3a85f7e57490b

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Citations in the corpus

• Nervous system involvement after infection with COVID-19 and other coronaviruses (2020, background): “abnormally initiated in severe pneumonia caused by CoV infection, while early anti-inflammatory intervention effectively prevent immune damage and reduce the risk of injury in the nervous system (Mehta et al., 2020; Fu et al., 2020).”
• Virology, Epidemiology, Pathogenesis, and Control of COVID-19 (2020, background): “with immunoglobulin (IVIG), and systemic anti-inflammatory drugs to reduce cytokine storm are also potential therapeutic strategies for severe COVID-19 [61,79].”
• Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis (2020, background): “While anti-inflammatory dietary constituents may be beneficial during hyper-inflammation, such as the COVID-19 cytokine storm, care should be taken against high doses of isolated anti-inflammatory compounds and/or antioxidants during healthier conditions in order to not suppress inflammation and the”