V(D)J recombination: RAG proteins, repair factors, and regulation.

By M. Gellert. Annual Review of Biochemistry, 2002

788 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/399e75520cc5806549406f4d2dd86090ff4e6da4

How researchers see this paper

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In Immunology

1. David H. Jung
2. M. Lieber
3. F. Alt
4. Cédric Feschotte
5. Michael J Hendzel
6. D. Schatz
7. D. Chaplin
8. H. Ilves

In Molecular Biology

1. R. Voss
2. S. Jansa
3. Cédric Feschotte
4. F. Alt
5. David H. Jung
6. Michael J Hendzel
7. D. Schatz
8. D. Chaplin

In Oncology

1. David H. Jung
2. Cédric Feschotte
3. Michael J Hendzel
4. D. Schatz
5. F. Alt
6. D. Chaplin
7. H. Ilves
8. R. Voss

Citations in the corpus

• Unraveling V(D)J Recombination: Insights into Gene Regulation (2004, positive): “…and Baltimore successfully developed an Post-RAG: Advances and Outstanding Questions To initiate the cleavage reaction, RAG binds first to one (12 or 23) and then to a second (23 or 12) RS (JonesRegarding V(D)J Recombination Making the Cut—RAG-Mediated DNA and Gellert, 2002; Mundy et al., 2002).”
• Phylogenetic Relationships and Classification of Didelphid Marsupials, an Extant Radiation of New World Metatherian Mammals (2009, background): “…recognition sequences, initiating recombination of variable (V), diversity (D), and joining (J) gene segments; completion of the V(D)J rearrangement process yields functional immunoglobulin and T-cell receptor proteins, an essential step in the development of a mature immune system (Gellert, 2002).”
• The γ‐H2A.X: Is it just a surrogate marker of double‐strand breaks or much more? (2008, background): “, 2000], V (D) J splicing [Chen et al., 2000; Gellert, 2002], and class switch recombination [Petersen et al.”
• Stress-induced transposition of Tn4652 in Pseudomonas putida (2006, background): “The V(D)J recombination responsible for the immune repertoire of vertebrates is claimed to be evolved from an ancient TE (Agrawal et al., 1998; Plasterk, 1998; Zhou et al., 2004; Kapitonov and Jurka, 2005; reviewed in Gellert, 2002).”
• DNA transposons and the evolution of eukaryotic genomes. (2007, methodology): “Additional support for the relationship came from comparisons of the structure of the RSS to the TIRs of Transib transposons and the conservation of spatial and sequence characteristics [the so-called 12/23 rule; (58)].”
• Recombination centres and the orchestration of V(D)J recombination (2011, background): “Nicking is less tightly regulated and can occur in the signal or paired comple”
• Overview of the Immune Response (2003, background): “4 The assembly of these gene elements is initiated by the lymphoid-specific recombinase-activating gene (RAG) 1 and RAG2 proteins, which cleave the DNA near the V, D, and J segments, and the gene segments are rejoined by a collection of non–lymphoid-specific DNA repair enzymes, including DNA-depende”
• The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway (2010, background): “The RAG complex initially nicks directly adjacent to each RSS and then uses that nick as a nucleophile to attack the antiparallel strand at each of the non-RSS ends (137).”