Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.

By Xueliang Du, T. Matsumura, D. Edelstein, L. Rossetti, Z. Zsengellér, C. Szabó, M. Brownlee. Journal of Clinical Investigation, 2003

820 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/397b1b3e19a0793441b5e7e938544a73486b5671

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. E. Schiffrin
2. M. Brownlee

In Oncology

1. M. Brownlee

In Pathology and Forensic Medicine

1. M. Brownlee

Citations in the corpus

• Oxidative Stress and Diabetic Retinopathy (2007, background): “The inhibition of glyceraldehyde 3 phosphate dehydrogenase (GAPDH), a multifunctional protein with diverse cytoplasmic membrane and nuclear activities, by ROS causes the diversion of all glycolytic metabolites to the hexosamine pathway producing UDP-N-acetylglucosamine which is a substrate used for ”
• The pathobiology of diabetic complications: a unifying mechanism. (2005, methodology): “Both hyperglycemia-induced processes are prevented by either UCP-1 or MnSOD (46).”
• The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “The reduction of GADPH activity can be prevented by MnSOD [145–147].”
• Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications (2020, background): “pathway with the increasing influx of phosphorylated glucose [87,88].”
• A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy (2011, background): “That gene disruption of GADPH also amplifies the abovenamed cellular events lends support to the hypothesis that GADPH plays a critical role in the generation of mitochondrial ROS (61).”
• Vascular complications of diabetes: mechanisms of injury and protective factors (2013, background): “Alternatively, increased DAG synthesis can occur from the glycolytic intermediate dihydroxyacetone phosphate which accumulates when the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is inhibited by poly(ADPribosyl)ation during high glucose concentrations (Du et al., 2003).”
• Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “Hyperglycemia reduces glucose-6-phosphate dehydrogenase (G6PDH)-mediated entry of glucose into the pentose phosphate pathway, but rather into the polyol pathway through conversion to sorbitol by the rate-limiting enzyme AR, and these processes are accompanied by a decrease in the rate of NADPH (an i”
• Endothelial dysfunction. (2004, background): “Other sources include xanthine oxidase (13), the mitochondria (36), and uncoupled NOS.”