LKB1-dependent signaling pathways.

By D. Alessi, K. Sakamoto, J. Bayascas. Annual Review of Biochemistry, 2006

810 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/38c296985074f4b45a728a1bf09afdb2f0a540f1

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Citations in the corpus

Protein tyrosine phosphatases: from genes, to function, to disease (2006, background): “This situation is again reminiscent of examples encountered among the protein kinases, including STRAD , which is a Ste20-like pseudokinase that regulates the function of the tumour suppressor kinase LKB1, a member of the AGC family of kinase”
The PAR proteins: fundamental players in animal cell polarization. (2007, neutral): “, 2004), although PAR-4 is expressed ubiquitously (Alessi et al., 2006).”
AMPK is a negative regulator of the Warburg Effect and suppresses tumor growth in vivo (2012, background): “The upstream AMPK-activating kinase LKB1 is a tumor suppressor gene inactivated in patients with PeutzJegher’s syndrome (Alessi et al., 2006), a condition that predisposes patients to gastrointestinal polyps and malignant tumors (Giardiello et al.”
New Users of Metformin Are at Low Risk of Incident Cancer (2009, background): “A plausible biological mechanism hinges on the discovery that the upstream LKB1 regulator of AMPK is a tumor suppressor and that activation of AMPK by LKB1 plays an important role in inhibiting cell growth when cellular energy levels are low (17).”
A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3) (2012, neutral): “It is best characterized as a scaffolding protein in a heterotrimer with the STRAD pseudokinases and the LKB1 (liver kinase B1) tumour suppressor kinase [3].”
Update on the treatment of type 2 diabetes mellitus. (2016, background): “LKB1 is a tumour suppressor, and activation of AMPK through LKB1 [62] may play a role in inhibiting cell growth.”
Peutz–Jeghers syndrome: a systematic review and recommendations for management (2010, positive): “It is also involved in cell metabolism and energy homeostasis.(30) It is an upstream regulator of AMP activated protein kinase (AMPK), thereby regulating the TSC pathway and acting as a negative regulator of the mammalian target of rapamycin (mTOR) pathway.”
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (2010, background): “In LKB1-deficient HeLa cells or Lkb1 MEFs, AMPK is not activated by agonists such as AICAR or metformin; however, AMPK possesses significant basal activation and phosphorylation at Thr172, suggesting that other AMPKkinases can compensate to regulate the key metabolic processes controlled by AMPK (30”
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse (2008, background): “Also notably, PAR1 is a downstream target of LKB1/PAR4 kinase, loss-of-function mutations of which lead to the gastrointestinal cancer-prone Peutz–Jeghers syndrome (39).”