Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

By Naomi Ohnishi, H. Yuasa, Shinya Tanaka, H. Sawa, M. Miura, A. Matsui, H. Higashi, M. Musashi, K. Iwabuchi, Misao Suzuki and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

612 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/af7a976419d3e5b761899d282fa7c35cd5e3f859

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Y. Yamaoka
2. R. Peek
3. Keith T. Wilson
4. Lydia E. Wroblewski

In Molecular Biology

1. Anica M Wandler
2. Crystal M. Botham
3. K. Guillemin

In Surgery

1. Y. Yamaoka
2. R. Peek
3. Keith T. Wilson
4. Lydia E. Wroblewski

Citations in the corpus

• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “The only direct evidence of oncogenicity of the CagA protein in vivo is in transgenic mice overexpressing a virulent form of the cagA gene (Ohnishi et al., 2008).”
• A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor (2008, background): “pylori infection, CagA provides a tissue specific activation of RTK signaling that can precipitate events leading to gastric carcinogenesis [37], as suggested by a recent report of CagA-expressing transgenic mice [38].”
• Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “Cell culture and animal models often provide conflicting data, and pathological changes reported for transgenic CagA mice occurred in the absence of inflammation, which is in stark contrast to what is seen in humans (231).”
• Mechanisms of disease: Helicobacter pylori virulence factors (2010, background): “Since then, another study reported that gastric cancer and other malignant neoplasms occurred in some transgenic mice that had CagA protein artificially introduced”
• Helicobacter pylori: gastric cancer and beyond (2010, background): “Transgenic expression of CagA in mice leads to gastric epithelial cell proliferation and carcinoma development, and CagA attenuates apoptosis in vitro and in vivo — implicating this molecule as a bacterial oncoprotei”