Molecular evolution of FOXP2, a gene involved in speech and language

By Wolfgang Enard, M. Przeworski, Simon E. Fisher, Cecilia S. L. Lai, V. Wiebe, T. Kitano, A. Monaco, Svante Pääbo. Nature, 2002

1,437 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/385cb39f5e0c1f904edcb8e3ecd741928cd35c5f

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Citations in the corpus

The Social Brain: Mind, Language, and Society in Evolutionary Perspective (2003, result): “This is also in broad general agreement with recent genetic evidence suggesting that two key point mutations, which seem to be associated with grammatical competence (FoxP2 genes on chromosome 7), are likely to have appeared within the last 200 KY (Enard et al. 2002; see also Lai et al. 2001).”
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance (2014, background): “Since the time that the human and chimpanzee lineages separated, approximately 6 Mya, two amino acid substitutions have occurred in FOXP2, a higher rate of change than expected given its conservation in mammals (2, 3).”
The evolution of Fox genes and their role in development and disease (2009, background): “Human-specific changes in the amino-acid sequence of FOXP2, as well as the polymorphism pattern, and cosegregation of a point mutation in FOXP2 in a family with speech impairment, are consistent with adaptive evolution of FOXP2 during human evolutio”
The faculty of language: what's special about it? (2005, positive): “…universal in the human population, that it diverged from the primate homologue subsequent to the evolutionary split between humans and chimpanzees, and that it was a target of natural selection rather than a product of genetic drift or other stochastic evolutionary processes (Enard et al., 2002).”
FOXP2 as a molecular window into speech and language. (2009, methodology): “logues, two (T303N, N325S) occurred on the human lineage at some point after splitting from the chimpanzee lineage some 5–6 million years ago [ 56 ,57].”
The evolution of transcriptional regulation in eukaryotes. (2003, background): “…1-or 2-dimensional protein gels in a variety of organisms: Zea mays (Burstin et al. 1994; Damerval et al. 1994; de Vienne et al. 2001), Pinus pinaster (Costa and Plomion 1999), Glycine max (Gerber, Fabre, and Planchon 2000), Mus musculus (Klose et al. 2002), and Homo sapiens (Enard et al. 2002 a ).”
Child Language Acquisition: Contrasting Theoretical Approaches (2013, background): “Enard et al. (2002), Vargha-Khadem et al. (1995)), they call our attention to the complexity of gene-behavior relationships, and suggest that the extent to which the FOXP2 gene is specific to language still requires detailed investigation.”
Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data (2011, neutral): “Additionally, adaptive functionality often results from mutations in previously highly constrained sites 25–27 , suggesting that constraint-based measures are effective even for regions with species-specific functional alterations.”
Ecology in an anthropogenic biosphere (2015, background): “…traits, some of which have been identified recently as specific to Homo sapiens, including a variant of FoxP2 (a protein involved in brain development and language), among others (Enard et al. 2002, Tomasello et al. 2005, Laland et al. 2010, Dean et al. 2012, Fisher and Ridley 2013, Pääbo 2014).”
Comparative Genomics (2007, positive): “Some genes that are candidates for human-specific selection lead to intriguing and exciting possibilities, such as alterations in FOXP2 implicated in language acquisition (Enard et al. 2002) and MCPH1 and ASPM implicated in brain size (Evans et al. 2005; Mekel-Bobrov et al. 2005).”