Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

By K. Takeda, Y. Hayakawa, M. Smyth, N. Kayagaki, N. Yamaguchi, S. Kakuta, Y. Iwakura, H. Yagita, K. Okumura. Nature Medicine, 2001

796 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37e0e8969dd8523b3d1a72bc67a7c5ae177465b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Ashkenazi
2. M. Smyth
3. J. Massagué
4. Alexandru Almasan
5. H. Yagita
6. K. Takeda
7. Ricky W. Johnstone
8. Heidi N. Leblanc

In Molecular Biology

1. A. Ashkenazi
2. J. Massagué
3. Scott W. Lowe
4. Alexandru Almasan
5. Ricky W. Johnstone
6. M. Smyth
7. Heidi N. Leblanc
8. K. Takeda

Citations in the corpus

• Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “TRAIL TNF family death ligand Mice depleted of NK cells or treated with a TRAIL-blocking antibody exhibited a significant increase in spontaneous liver metastasis [41,42].”
• Apo2L/TRAIL and its death and decoy receptors (2003, background): “In the mouse, Apo2L/TRAIL is expressed on liver natural killer (NK) cells, but not on other lymphocytes isolated from liver or spleen.(72) Blocking Apo2L/TRAIL partially prevents liver NK cell cytotoxicity in vitro, and dramatically increases liver metastasis of Apo2L/TRAIL-sensitive cell lines in v”
• Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. (2003, background): “[106] Takeda K, Hayakawa Y, Smyth MJ, Kayagaki N, Yamaguchi N, Kakuta S, et al.”
• Cancer metastasis: building a framework. (2006, background): “(Takeda et al., 2001), are both mechanisms that facilitate hepatic metastasis in mouse models.”
• Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice1 (2002, methodology): “Using the anti-TRAIL mAb, we found that some murine liver NK cells constitutively expressed TRAIL, which was at least partly responsible for natural antimetastatic function of liver NK cells against TRAIL-sensitive tumor cells (13).”
• How Do Cytotoxic Lymphocytes Kill Cancer Cells? (2015, background): “This effect was originally shown using transplanted syngeneic cell lines (11, 54, 60, 61) and later confirmed in a more physiologic model of spontaneous metastasis during chemically induced carcinomas (62).”
• Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “For example, in primary lympho-Takeda et al., 2001).”