Active demethylation of the paternal genome in the mouse zygote.

By J. Oswald, S. Engemann, Natasha Lane, W. Mayer, A. Olek, R. Fundele, W. Dean, Wolf Reik, Jörn Walter. Current Biology, 2000

1,051 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/373518fe574e3113920204212237c062122faa7e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. E. Li
5. A. Bird
6. W. Dean
7. Jörn Walter
8. R. Jaenisch

In Molecular Biology

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. A. Bird
5. E. Li
6. W. Dean
7. R. Jaenisch
8. K. Hochedlinger

In Pediatrics, Perinatology and Child Health

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. E. Li
5. Jörn Walter
6. W. Dean
7. Fátima Santos
8. A. Bird

Citations in the corpus

• DNA Methylation and Its Basic Function (2013, background): “Active DNA demethylation can occur in both dividing and nondividing cells but the process requires enzymatic reactions to process the 5mC in order to revert it back to a naked cytosine (Mayer et al, 2000; Oswald et al, 2000; Paroush et al, 1990; Zhang et al, 2007).”
• Uncovering the role of 5-hydroxymethylcytosine in the epigenome (2011, background): “Nonetheless, DNA methylation patterns undergo genome-wide reprogramming during the establishment of primordial germ cells (PGCs) and after fertilizatio”
• DNA methylation in cancer: too much, but also too little (2002, background): “…the global DNA demethylation, including satellite DNA demethylation, that occurs from the one-cell stage through the morula stage is reversed by genome-wide remethylation throughout the early murine embryoblast by 6.5 – 7.5 d.p.c. (Chapman et al., 1984; Oswald et al., 2000; Razin and Kafri, 1994).”
• DNA methylation patterns and epigenetic memory. (2002, background): “De novo methylation of proviral sequences in embryo cells depends on DNMT3A and DNMT3B (Okano et al. 1999), but initial retroviral shutdown occurs as usual even when both these de novo methyltransferases are absent (Pannell et al. 2000).”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, methodology): “%) and subjected to the bisulphite treatment followed by sequence specific PCR amplifications (Oswald et al., 2000).”
• Dynamic reprogramming of DNA methylation in the early mouse embryo. (2002, methodology): “Although the absence of DNA methylation from the male pronucleus has been established at specific loci by using bisulphite sequencing (Oswald et al., 2000), the possibility remains that some aspects of the genomewide loss might also be explained as a consequence of specific masking of the…”
• Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. (2005, background): “In contrast, the extent of CpG methylation is unchanged at two loci, the promoter regions of the a-actin gene and the alkaline myosin light chain (Myl-c) gene (Oswald et al., 2000),”
• Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair (2011, neutral): “However, there is evidence supporting the occurrence of active demethylation in mammals, including demethylation of the paternal genome shortly after fertilization (Mayer et al., 2000; Oswald et al., 2000), demethylation to erase and reset imprinting in primordial germ cells (Reik et al.”