Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

By S. Chiang, C. Baumann, M. Kanzaki, D. Thurmond, R. Watson, C. L. Neudauer, I. Macara, J. Pessin, Alan R. Saltiel. Nature, 2001

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Rho GTPases in cell biology (2002, background): “Finally, insulin stimulation of adipocytes induces translocation of intracellular vesicles containing glucose transporters, and TC10, a relatively uncharacterized member of the Rho family, is require”
Role of caveolae and caveolins in health and disease. (2004, background): “Additional experimentation revealed that insulin treatment of these cells results in the association of the glucose transporter GLUT4 with caveolin-enriched membrane microdomains, as well as the tyrosine phosphorylation of caveolin-1 on residue 14 (22, 31, 32, 112, 122, 215).”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “TC10 is a Rho-like GTPase that is highly expressed in adipocytes and skeletal muscle (115).”
Ras proteins: different signals from different locations (2003, background): “So H-ras, but not K-ras, signalling requires intact lipid rafts; a similar dependence on intact rafts for signalling is shown by TC10, which has an almost identical membrane anchor to H-ra”
Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival (2003, background): “Akt has also been shown to regulate the localization of Glut4 in myoblasts and adipocytes, as insulin-stimulated translocation of Glut4 has been shown to depend on both the Rho family GTPase TC10 and the phosphatidylinositol 3-kinase/Akt pathway (9, 55).”