Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fcγ Receptors1

By Charles F. Anderson, D. Mosser. Journal of Immunology, 2002

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Biochemical and functional characterization of three activated macrophage populations (2006, methodology): “IC were made by mixing a tenfold molar excess of rabbit anti-OVA IgG (Cappel, Durham, NC) to OVA (Worthington, Lakewood, NJ) for 30 min at room temperature, as described [ 11 ].”
Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences1 (2005, background): “2) Fc R ligation (24) and low dose LPS pretreatment (25–27) have been reported to result in unique patterns of cytokine production upon subsequent stimulation with LPS.”
The Isolation and Characterization of Murine Macrophages (2008, methodology): “This protocol has been used to examine the functional capabilities of macrophages under different external stimulation conditions (Warren and Vogel, 1985; Anderson and Mosser, 2002).”
A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease (2002, background): “IC themselves may also enhance antibody production and promote a Th2 bias of the immune response ( 15 ).”
Macrophage activation by endogenous danger signals (2008, background): “These cells can skew T helper cell responses by inducing T cells to produce IL-4 [119].”