T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.
By Ming O. Li, Y. Wan, R. Flavell. Immunity, 2007
811 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/3683eb4bf880993724ac419b8d518afe198cc1d2
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Alexander Y. Rudensky
- Steven Z. Josefowicz
- V. Kuchroo
- Li-Fan Lu
- J. Bluestone
- P. Krammer
- Angelika Schmidt
- Nina Oberle
Citations in the corpus
- The Foxp3+ regulatory T cell: a jack of all trades, master of regulation (2008, background): “In a few in vivo models, expression of IL-10 or TGF-β specifically in T reg cells is required for T reg cell functio”
- Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis (2011, methodology): “Mice homozygous for the TGF b 1 floxed allele ( TGF b 1 fl/fl ; obtained from R. Flavell) (Li et al., 2007) on a C57BL/6 genetic background were crossed with Pf4-cre mice on a C57BL/6 background (obtained from S. Shattil) (Tiedt etal.,2007).”
- IL-17 and Th17 Cells. (2009, background): “In the follow-up study (9), they showed that IL-23 expands/generates IL-17-producing T cells that are capable of inducing EAE when adoptively transferred into naive wild-type mice.”
- TGF-β Activation and Function in Immunity (2013, background): “by Tregs was critical for suppression of disease in a T cell transfer colitis model (132), another study showed that TGF-β1−/− Tregs were fully capable of suppressing colitis (84).”
- Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “…deficiency showed enhanced Th1 and Th2 responses and immunopathology including colitis, underscoring the importance of T cell-produced TGF-β; however, these mice were resistant to the induction of experimental autoimmune encephalitis (EAE) likely due to impaired Th17 induction (Li et al., 2007).”
- Identification of CD25+ γδ T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers1 (2008, background): “Differentiation of Th17 depends on TGFand several proinflammatory cytokines including IL-6 (6).”