Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

By H. van Praag, Gerd Kempermann, Fred H. Gage. 1999

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “We also find that proliferating progenitors and young neurons in the DG sharply decline in the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age.”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “For example, in the adult SGZ, physical exercise increases cell proliferation (van Praag et al., 1999), while an enriched environment promotes new neuron survival (Kempermann et al., 1997).”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “Adult neurogenesis can be enhanced by a number of extrinsic factors, including exercise, enriched environment, and learning (Kempermann et al., 1997; Gould et al., 1999; Van Praag et al., 1999).”
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus (2004, background): “…et al., 1999), neu- rotransmitter levels (Gould et al., 1994; Brezun and Daszuta, 1999), enriched environments (Kempermann et al., 1997), running (Van Praag et al., 1999), lithium treatment (Chen et al., 2000), chronic alcohol administration (Cadete-Leite et al., 1988; Herrera et al., 2003), and…”
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus (2005, background): “This ongoing neurogenesis has been involved in learning and memory in young and old rats (van Praag et al., 1999; Lemaire et al., 2000; Drapeau et al., 2003).”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “Female C57BL/6 mice, 6 –7 weeks of age, were housed with a running wheel, which is known to enhance adult hippocampal neurogenesis, increasing the efficiency of viral transduction (van Praag et al., 1999).”
Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus (2003, background): “…psychosocial stress (Gould et al., 1997; Gould et al., 1998), oestrogen (Tanapat et al., 1999), enriched environments (Kempermann et al., 1997; Kempermann et al., 1998), physical activity (van Praag et al., 1999a; van Praag et al., 1999b), and learning and memory exercises (Gould et al., 1999).”
Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis (2000, background): “Thus, changes in such diverse factors as stress (Cameron and Gould, 1994; Gould et al., 1997, 1998), learning (Gould et al., 1999), exercise (van Praag et al., 1999), environmental stimulation (Kempermann et al., 1998a,b), neurotransmitters and hormones (Cameron et al., 1995; Brezun and Dazsuta,…”
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats (2010, unknown): “…and BrdU-positive cells, these cells were counted manually by means of a modified stereological procedure using a Zeiss microscope (×200 magnification) and multiplied by 10 to estimate the total number of Ki-67-positive and BrdU-positive cells in the DG (Oomen et al. 2007; van Praag et al. 1999).”
From house mouse to mouse house: the behavioural biology of free-living Mus musculus and its implications in the laboratory (2004, background): “…and/or providing opportunities to move under cover can increase brain weight and alter the relative weights of different brain structures (e.g. Katz and Davies, 1984; Kempermann et al., 1997), and increase neural connectivity and neurogenesis (van Praag et al., 1999a,b; Nakamura et al., 1999).”