Allocation concealment in randomised trials: defending against deciphering.

By K. F. Schulz, D. Grimes. The Lancet, 2002

907 citations recorded by the source corpus.

Subfields: Economics and Econometrics, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/36443b34f55cfa9140460a324c1980deb1147b3e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Economics and Econometrics

In Statistics and Probability

Citations in the corpus

ILAE Treatment Guidelines: Evidence‐based Analysis of Antiepileptic Drug Efficacy and Effectiveness as Initial Monotherapy for Epileptic Seizures and Syndromes (2006, methodology): “Ideally, details on the randomization procedure for each study would have been incorporated into this bias assessment because poor concealment of randomization can have considerable impact on the estimates of treatment effects (7); unfortunately”
In Pursuit of Balance: Randomization in Practice in Development Field Experiments (2008, neutral): “For example, Schulz and Grimes (2002) report that in the clinical trials literature, researchers who use hypothesis tests to compare baseline characteristics report fewer significant results than expected by chance.”
An overview of randomization techniques: An unbiased assessment of outcome in clinical research (2011, neutral): “Knowledge of group assignment creates a layer of potential selection bias that may taint the data.[9] Schul and Grimes stated that trials with inadequate or unclear randomization tended to overestimate treatment effects up to 40% compared with those that used proper randomization.”
Reporting animal research: Explanation and Elaboration for the ARRIVE guidelines 2019 (2019, background): “It helps minimise selection bias and reduce systematic differences in the characteristics of animals allocated to different groups [57-59].”
CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration (2008, background): “, allocation by a central office) or pharmacy-controlled randomization; sequentially numbered identical containers that are administered serially to participants; on-site computer system combined with allocations kept in a locked, unreadable computer file that investigators can access only after the”
Can Animal Models of Disease Reliably Inform Human Studies? (2010, result): “Clinical trials in which authors did not report randomisation, adequately conceal treatment allocation, or use double blinding yielded larger estimates of treatment effects than trials in which these study quality issues were reported [12,27–32].”