Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

By C. Haag-Liautard, M. Dorris, X. Maside, S. Macaskill, Daniel L. Halligan, B. Charlesworth, Peter D. Keightley. Nature, 2007

392 citations recorded by the source corpus.

Subfields: Genetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/361b7251fa68b9101693fc2df863432ea52d8d97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Robert
2. M. J. Phillips
3. Simon Y. W. Ho
4. Yong‐Zhen Zhang
5. Edward C. Holmes
6. Colin N. Dewey
7. Michael Lynch
8. Peter D. Keightley

In Plant Science

1. A. Robert
2. Yong‐Zhen Zhang
3. Matthew W. Hahn
4. Lior S. Pachter
5. Simon Y. W. Ho
6. Edward C. Holmes

Citations in the corpus

• Accounting for calibration uncertainty in phylogenetic estimation of evolutionary divergence times. (2009, background): “…sampled from individuals with a known degree of intergenerational separation, which can be the case for data obtained from studies of pedigrees and of mutation accumulation lines (e.g., Howell et al. 2003; Haag-Liautard et al. 2007); in these cases, the age of at least one internal node is known.”
• Captive breeding genetics and reintroduction success (2009, methodology): “Genetic factors were parameterized using values from a broad array of empirical studies (Haag-Liautard et al., 2007).”
• Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans (2007, result): “Estimates of small-indel heterozygosity for the X chromosome and autosomes (Table S1) were lower than estimates of nucleotide heterozygosity [31].”
• A genome-wide view of the spectrum of spontaneous mutations in yeast (2008, background): “99 per generation (8), and although considerable disagreement exists on the genome-wide deleterious rate in this species, most plausible estimates fall in the range of 0.”
• The Evolution and Emergence of RNA Viruses (2009, background): “Remarkably, the estimates of U in some RNA viruses are extremely similar to those estimated for higher eukaryotes, at approximately U=1 (Haag-Liautard et al. 2007), although in the context of much smaller genomes.”
• Spontaneous Mutation Accumulation Studies in Evolutionary Genetics (2009, background): “This yields an estimate of U for Drosophila of about 0.6 per haploid genome (Haag-Liautard et al. 2007).”