TGFbeta signaling in growth control, cancer, and heritable disorders.

By J. Massagué, S. Blain, R. Lo. Cell, 2000

2,563 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/35ea637cd8b8740aa03ef048027211ffad144592

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Citations in the corpus

Role of tissue stroma in cancer cell invasion (2003, unknown): “Mutations in TGF-βRII are frequently found in cancers with microsatellite instability, such as colon cancer [78].”
Transforming Growth Factor- 1 to the Bone (2005, unknown): “Furthermore, transfection of dominant-negative forms of MAPK signaling intermediates or application of inhibitors of these components interferes with TGF- related processes or luciferase transcriptional activity from a TGF-responsive reporter construct in various cell lines, whereas overexpression o”
Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, unknown): “One of the major developments in recent years has been the realization that the signaling pathways triggered by these factors are very often deregulated in pathological conditions (Massague et al. 2000; Polakis 2000; Waite and Eng 2003; Bijlsma et al. 2004; Lefort and Dotto 2004; Moon et al. 2004).”
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance (2005, unknown): “TGF-β signaling involves its binding to a serine/threonine kinase receptor complex formed by receptor types I and II, followed by receptor-mediated phosphorylation of Smad2 and Smad3 (reviewed in Shi and Massagué [2003]; Massagué et al. [2000]).”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, unknown): “…suppressor and complexities of transforming growth factor- (TGF- ) signaling Another frequent event associated with PDAC progression is loss of the SMAD4 (DPC4) transcriptional regulator (Hahn et al. 1996), which serves as a central component in the TGF- signaling cascade (Massague et al. 2000).”
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage (2002, unknown): “TGF-β regulates gene expression through Smad transcription factor”
A multigenic program mediating breast cancer metastasis to bone. (2003, unknown): “When these cells were inoculated into athymic mice, Massagué et al., 2000).”