Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm.

By Lesley K. Fellows, Martha J. Farah. Brain : a journal of neurology, 2003

638 citations recorded by the source corpus.

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In Cognitive Neuroscience

Citations in the corpus

The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. (2005, background): “Maia and McClelland suggest that the difficulties of patients with ventromedial prefrontal cortex (VMPC) damage in IGT performance can be explained by an inability to reverse a learned contingency that such patients sometimes exhibit [ 11 ].”
Orbitofrontal cortex and its contribution to decision-making. (2007, result): “Only patients with OFC damage have problems with reversal learning: Patients with damage to DLPFC are unimpaired (Fellows & Farah 2003), consistent with the previous findings in monkeys.”
Childhood poverty: specific associations with neurocognitive development. (2006, background): “Reversal learning is impaired in humans after damage to ventromedial cortex (Fellows and Farah, 2003).”
Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. (2006, background): “Modified from Fellows and Farah (2003) with permission. b: Model reversal learning results.”
Reflecting upon Feelings: An fMRI Study of Neural Systems Supporting the Attribution of Emotion to Self and Other (2004, background): “…defined as z < 0) regions of the MPFC have been strongly associated with representing the affective value of stimuli (e.g., Lane & McRae, in press; Fellows & Farah, 2003; Bechara, Damasio, & Damasio, 2000), in part because of connections with the amygdala and autonomic centers that are more…”
The neural architecture of emotion regulation (2007, result): “Consistent with these findings, neuropsychological studies have shown impairments of stimulus-reinforcer reversal learning in patients with lesions of ventral and orbital but not dorsolateral PFC (Fellows & Farah, 2003, 2004; Hornak et al., 2004).”
Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency (2004, neutral): “humans (Fellows and Farah, 2003), our monkeys with bilateral”
The Common Neural Basis of Exerting Self-Control in Multiple Domains (2009, neutral): “Similar to the animal literature, human lesion studies consistently implicate the OFC as crucial for successful reversal learning (Fellows & Farah, 2003; Rolls et al., 1994).”
Socioeconomic gradients predict individual differences in neurocognitive abilities. (2007, methodology): “In this task, adapted from Fellows and Farah (2003), subjects play a computerized card game, in which they are dealt two cards at a time from decks of different colors.”
Revealing Neurocomputational Mechanisms of Reinforcement Learning and Decision-Making With the hBayesDM Package (2016, methodology): “The PRL has been also used to study decision-making deﬁcits associated with prefrontal cortex lesions (e.g., Fellows & Farah, 2003; Rolls, Hornak, Wade, & McGrath, 1994), as well as Parkinson’s disease (e.g., Cools, Lewis, Clark, Barker, & Robbins, 2007; Swainson et al., 2000), schizophrenia (e.g.,…”
Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART) (2008, background): “Patients with lesions in the DLPFC have demonstrated impairments inmakingoptimal choices during risky situations (Manes et al., 2002; Fellows and Farah, 2003).”
Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. (2008, background): “Using a probabilistic learning and reversal task where subjects must acquire and then reverse a two-choice visual discrimination, a task reported to be dependent on the integrity of the OFC (Fellows and Farah, 2003), a recent study also reported intact performance in (largely medicated) patients wit”