Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends

By C. Azzalin, P. Reichenbach, L. Khoriauli, E. Giulotto, J. Lingner. Science, 2007

1,317 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/35b4856e99a201d9b2b0ecad6af05a86da059682

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In Molecular Biology

1. Howard Y. Chang
2. M. Blasco
3. Roderick J. O’Sullivan
4. J. Karlseder
5. John S. Mattick
6. D. Rhodes
7. H. Lipps
8. D. Hockemeyer

In Physiology

1. J. Karlseder
2. M. Blasco
3. Roderick J. O’Sullivan
4. T. de Lange
5. D. Hockemeyer
6. Agnel Sfeir
7. Sheila L. MacRae
8. C. Schildkraut

In Plant Science

1. John S. Mattick
2. T. de Lange
3. Howard Y. Chang
4. J. Karlseder
5. M. Blasco

Citations in the corpus

• Distinct factors control histone variant H3.3 localization at specific genomic regions (2010, methodology): “In particular, TERRA has recently been identified as a component of telomeric heterochromatin, and levels of TERRA have been shown to be regulated by chromatin modifying enzymes (Azzalin et al., 2007; Luke and Lingner, 2009; Schoeftner and Blasco, 2008).”
• Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II (2008, background): “Note added in proof: while this manuscript was in the submission process, discovery of telomere transcripts in human cells was also reporte”
• Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication (2009, positive): “TotalcellularRNAwaspreparedwiththeRNeasyMiniKit(QIAGEN),according to the manufacturer’s instructions, and northern blot analysis was performed as previously described (Azzalin et al., 2007).”
• Molecular mechanisms of long noncoding RNAs (2011, background): “…the DNA-protein complexes located at the physical ends of eukaryotic chromosomes that are essential for chromosome stability, have been found to be transcribed into telomeric repeat-containing RNA (TERRA), a lncRNA, which forms an integral part of telomeric heterochromatin (Azzalin et al., 2007).”
• Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “They contain UUAGGG repeats and range from 100 bp to 9 kb in length [15].”
• Telomeres: protecting chromosomes against genome instability (2010, background): “However, transcription of the C-strand of telomeres by RNA polymerase II produces long UUAGGG-containing transcripts that are regulated by the nonsense-mediated decay pathwa”
• The Genetic Signatures of Noncoding RNAs (2009, background): “TERRA / TelRNAs Various sizes; transcribed from and associated with telomeres; contain UUAGGG repeats May form G-quartet structures with telomere DNA; inhibit telomerase activity RNA FISH; oligo-nucleotide inhibition [219,220]”
• G-quadruplexes and their regulatory roles in biology (2015, background): “The long G-rich telomere repeat containing RNA (TERRA) that result from the transcription of human and yeast telomeric DNA (106,107) unsurprisingly adopt Gquadruplex structures in vitro (26,108).”
• 5′-UTR RNA G-quadruplexes: translation regulation and targeting (2012, background): “A noteworthy recent example of the potential importance of RNA G-quadruplex emerged from the discovery of 100to 9000-nt G-rich telomeric repeat-containing RNAs (TERRA), which arise from RNA polymerase II transcription of the C-rich strand human DNA telomeres (44,45).”