Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II

By Stefan Schoeftner, M. Blasco. Nature Cell Biology, 2008

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5′-UTR RNA G-quadruplexes: translation regulation and targeting (2012, background): “A noteworthy recent example of the potential importance of RNA G-quadruplex emerged from the discovery of 100to 9000-nt G-rich telomeric repeat-containing RNAs (TERRA), which arise from RNA polymerase II transcription of the C-rich strand human DNA telomeres (44,45).”
The Genetic Signatures of Noncoding RNAs (2009, background): “TERRA / TelRNAs Various sizes; transcribed from and associated with telomeres; contain UUAGGG repeats May form G-quartet structures with telomere DNA; inhibit telomerase activity RNA FISH; oligo-nucleotide inhibition [219,220]”
Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “TERRA molecules have been characterized in rodents and humans [15, 18].”
Telomeres: protecting chromosomes against genome instability (2010, background): “However, transcription of the C-strand of telomeres by RNA polymerase II produces long UUAGGG-containing transcripts that are regulated by the nonsense-mediated decay pathwa”