Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
By M. Capecchi. Nature reviews genetics, 2005
715 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/35b32ee5ff7a1223bbabc171a66a5d216d3f18d8
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Citations in the corpus
- Trends in oxidative aging theories. (2007, background): “As in most areas of biology, gene-targeting “knockout” technology [173] has revolutionized the study of oxygen free radicals and oxidative damage in aging and disease [174,175].”
- Genome Engineering With Zinc-Finger Nucleases (2011, background): “Making targeted gene replacements has also become standard practice in mice, thanks to the availability of embryonic stem (ES) cells that can be manipulated in culture and the development of powerful selection procedures (Capecchi 2005).”
- Cell-type Specific Labeling of Synapses in vivo through Synaptic Tagging with Recombination (STaR) (2014, methodology): “In principle, the STaR method can be extended to the mouse and zebrafish through knockin and BAC transgenic tech- niques and through the use of multiple recombination systems (e.g., Cre-Lox and the B3 and KD systems) (Capecchi, 2005; Nern et al., 2011; Stuart et al., 1988).”
- Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts (2008, neutral): “In the past two decades, ES cells have been routinely used to create loss of function (knockout) or gene replacement (knockin) mutations by homologous recombination in the mouse, providing an invaluable tool for the functional characterization of genes (Capecchi, 2005).”
- One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013, neutral): “Mutant mice are conventionally generated by insertional mutagenesis (Copeland and Jenkins, 2010; Kool and Berns, 2009) or by gene-targeting methods (Capecchi, 2005).”