Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity

By B. Ozdamar, R. Bose, M. Barrios-Rodiles, Hong-Rui Wang, Yue Zhang, Jeffrey L. Wrana. Science, 2005

887 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/353ba7597f4a8309b6f148962c978b29389c752e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Nieto
2. R. Weinberg
3. A. Cano
4. J. Massagué
5. G. Moreno-Bueno
6. Jing Yang
7. A. Moustakas
8. C. Heldin

In Molecular Biology

1. R. Weinberg
2. M. Nieto
3. J. Massagué
4. A. Moustakas
5. C. Heldin
6. J. P. Thiery
7. A. Cano
8. Jing Yang

Citations in the corpus

• Cytokine regulation of tight junctions (2008, background): “Par6, an evolutionarily conserved regulator of cell polarity, is believed to act as a negative regulator of TJ establishment, yet may support TJ integrity through RhoA degradation [74,75].”
• Epithelial-mesenchymal transitions: insights from development (2012, background): “D E V E LO P M E N T 3480 dissolution of junctions (Ozdamar et al., 2005).”
• Complex networks orchestrate epithelial–mesenchymal transitions (2006, background): “The dissolution of tight junctions is an early step during EMT, and recent high-throughput protein–protein-interaction screens have revealed the molecular mechanisms through which TGFβ signalling regulates this proces”
• The regulation of TGFβ signal transduction (2009, background): “of intercellular tight junctions in mammalian cells (Ozdamar et al., 2005).”
• Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. (2006, background): “Aberrant regulation of RhoA www.aacrjournals.org 8323 Cancer Res 2006; 66: (17).”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Oncogenic EMT is associated with loss of apicobasal polarity [27], disintegration of tight junctions [28] and adherens junctions, cytoskeletal changes, including the downregulation of cytokeratins and the upregulation of vimentin [29], and the acquisition of a motile and invasive phenotype paralleli”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “…ways, through the canonical pathway by inducing Snail and Zeb genes expression and through a noncanonical pathway that involves the downregulation of Par3 expression and the Par6-mediated degradation of RhoA and local alteration of the actin cytoskeleton (Ozdamar et al., 2005; Wang et al., 2008).”
• Transforming Grown Factor-β Signaling in Immunity and Cancer (2019, positive): “TGFBR2 directly phosphorylates the cell polarity regulator PAR6, which regulates tight junctions and cell migration (Ozdamar et al., 2005; Yi et al., 2010).”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “In addition to marking SMAD proteins for degradation, Smurf1 marks RhoA GTPase for degradation, and the loss of RhoA promotes EMT through changes in the organization of actin filaments and the loss of tight junctions and adherens junctions (135).”
• Physiological functions of the HECT family of ubiquitin ligases (2009, background): “The transition leads to SMURF1 recruitment to the polarity complex and SMURF1-mediated ubiquitylation and degradation of RhoA, thus promoting the loss of tight junctions”