Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling

By B. Ohlstein, A. Spradling. Science, 2007

667 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3517416414591e6c7b05b0426b42d63aa0506e30

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. S. Morrison
2. Juergen A. Knoblich
3. M. Krummel
4. A. Wagers
5. A. Spradling

In Immunology

1. Nicolas Buchon
2. Juergen A. Knoblich
3. S. Morrison
4. N. Broderick
5. B. Lemaître
6. Bruce Edgar
7. Parthive H. Patel
8. D. McEwen

In Molecular Biology

1. S. Morrison
2. Juergen A. Knoblich
3. A. Spradling
4. A. Wagers
5. D. L. Jones
6. J. Rock
7. H. Chapman
8. E. Morrisey

Citations in the corpus

• Mechanisms of asymmetric stem cell division. (2008, background): “Stem cells are present in the adult gut (Ohlstein and Spradling, 2006, 2007), in the malpighian tubules (Affolter and Barde, 2007; Singh et al., 2007; Micchelli and Perrimon, 2006) and in the hematopoietic system (Krzemien et al., 2007; Mandal et al., 2007).”
• Basal cells as stem cells of the mouse trachea and human airway epithelium (2009, background): “This concept has been proposed for the Drosophila midgut, where varying levels of Notch ligand in the intestinal stem cells regulates the fates of their progeny (25, 26).”
• Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function (2014, methodology): “One model, based on studies of the intestinal stem cells of the Drosophila larval midgut (Lucchetta and Ohlstein, 2012; Ohlstein and Spradling, 2007) is that BCs give rise to Trp63−/Krt5+/Krt8+ early progenitors or “intermediate” cells that can proliferate and give rise to either secretory or…”
• Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. (2009, background): “The induction of many genes encoding components of signaling pathways associated with stem cell differentiation and maintenance (EGF-R, hedgehog, Notch, and JAK-STAT) (Choi et al., 2008; Ohlstein and Spradling, 2007) points to their role in the regulation of epithelial renewal upon infection.”
• Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling (2010, background): “The Notch signaling pathway regulates adult stem cells in a variety of vertebrate and invertebrate systems, including the skin, mammary gland, nervous system and gut (Blanpain et al., 2006; Ohlstein and Spradling, 2007; Visvader, 2009; Mazzone et al., 2010).”
• Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Intestinal stem cells divide asymmetrically such that only one daughter cell receives a (Notch) signal that specifies its fate (Ohlstein and Spradling, 2007).”
• No place like home: anatomy and function of the stem cell niche (2008, background): “Therefore, it appears that ISCs signal through Delta to activate Notch target genes in enteroblast”
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, methodology): “Since EB differentiation coincides with a reduction in their contact with a basement membrane, it has also been proposed that this membrane or underlying visceral muscle might provide a niche that promotes stemness and suppresses differentiation (Ohlstein and Spradling, 2007).”