Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

By B. Hogan, C. E. Barkauskas, H. Chapman, J. Epstein, Rajan Jain, C. Hsia, Laura E. Niklason, Elizabeth A. Calle, Andrew V Le, S. Randell and 8 more. Cell Stem Cell, 2014

817 citations recorded by the source corpus.

Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.

Subfields: Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/37d0043333e2020194b611f7ea3030770858c794

Citations in the corpus

• CellRank for directed single-cell fate mapping (2020, neutral): “In agreement with lineage tracing experiments 57 , we observed a high probability for club cells to give rise to ciliated cells (Fig.”