Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

By Jochen Schust, Bianca Sperl, A. Hollis, T. Mayer, T. Berg. Chemistry and Biology, 2006

1,086 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e4053495a1ebebbf0d28f9f9e212478a6a0fabe5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Wang-Gillam
2. M. V. D. van den Brink
3. Gautam Sethi
4. D. DeNardo
5. Yu Zhu
6. B. West
7. B. Knolhoff
8. D. Linehan

In Oncology

1. D. DeNardo
2. D. Linehan

In Pathology and Forensic Medicine

1. M. V. D. van den Brink
2. J. Dudakov
3. A. Hanash

Citations in the corpus

• Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses (2012, background): “inhibitors of STAT3 signaling [STATIC (37) and WP1066] and STAT3 short hairpin RNA (shRNA) constructs.”
• Interleukin-22 Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration (2015, positive): “However, IL-22 can also promote epithelial Stat1 signaling 14 , which Stattic has inhibitory activity against 15 .”
• Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “A non-peptide small molecule called Stattic selectively inhibits STAT3 by directly binding to the SH2 domain [288].”