Killing the messenger: short RNAs that silence gene expression

By D. Dykxhoorn, C. Novina, Phillip A. Sharp. Nature reviews. Molecular cell biology, 2003

1,281 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3482dfccd38fed33a5c812927483f00d7030bd52

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Citations in the corpus

Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “An alternative promising strategy for downregulating gene expression is through the use of RNAi (Dykxhoorn et al. 2003) that can be delivered to both mouse and human ES cells with lentiviruses (Hamaguchi et al.”
Thermodynamics of RNA-RNA Binding (2006, background): “Small interfering RNAs (siRNAs) are short (21-23nt) RNA duplices with symmetric 2-3 nt overhangs [10, 24, 25].”
Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome (2004, background): “…implicated in gene silencing in two independent modalities: at the RNA level through degradation of mRNAs and at the chromatin structure level through induction of PLoS Biology | www.plosbiology.org December 2004 | Volume 2 | Issue 12 | e3912155 methylation (Dykxhoorn et al. 2003; Ekwall 2004).”
Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage ϕ6 RNA-dependent RNA polymerase (2007, background): “In fact, in plants, fungi, and most invertebrates, full-length dsRNA molecules can be used to induce RNA silencing as such, enabling their potential use in the regulation of gene expression as well as a tool in functional genomics (Dykxhoorn et al. 2003; Meister and Tuschl 2004).”
RNA Interference: Biology, Mechanism, and Applications (2003, background): “crassa, and Dictyostelium discoideum but not in flies and mammals (66).”
Comparing the human and chimpanzee genomes: Searching for needles in a haystack (2005, background): “The wealth of new information being generated about noncoding RNA sequences also makes them an intriguing candidates for potential differences (Eddy 2001; Dykxhoorn et al. 2003; Mello and Conte 2004; Kim 2005; Tang 2005).”
1.3 – Vitellogenesis and Post-Vitellogenic Maturation of the Insect Ovarian Follicle (2005, background): “siRNAs subsequently become integrated into a multiprotein complex known as the RNAinduced silencing complex (RISC), where they function as guide RNAs to target homologous mRNAs for cleavage and degradation (Dykxhoorn et al., 2003).”