The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.

By L. Schaefer, A. Babelova, É. Kiss, H. Hausser, Martina Baliova, Miroslava Krzyzankova, G. Marsche, M. Young, D. Mihálik, M. Götte and 3 more. Journal of Clinical Investigation, 2005

852 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/34786deca1db73d5f7c2a81e53baf9cc0efa0e9d

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In Immunology

1. L. Sorokin
2. DM Mosser
3. X. Zhang
4. S. Goldring
5. N. Itano
6. Pawared Ontong
7. S. Sacre
8. C. Scanzello

Citations in the corpus

• Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “Soluble biglycan and its fragments act on macrophages to produce both TNF-α and MIP-2 in a manner that is dependent on TLR2 and TLR4, and thereby play a positive role in macrophage recruitment and activation [42].”
• The impact of the extracellular matrix on inflammation (2010, background): “This leads to the upregulation of CXCL2 and TNF expression by macrophages and creates a positive feed-forward mechanism that promotes macrophage infiltration and perpetuation of the inflammatory respons”
• Extracellular matrix structure. (2016, background): “Biglycan is also a proinflammatory molecule that activates TLRs [77, 78].”
• Macrophage activation by endogenous danger signals (2008, background): “Biglycan acts on macrophages to produce TNFα and MIP-2 in a TLR2- and TLR4dependent manner [67].”
• Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease (2009, background): “; however, biglycan can be immunoprecipitated with both TLR2 and TLR4 (ref”
• DAMPening Inflammation by Modulating TLR Signalling (2010, background): “Similarly, biglycan has been shown to signal through TLR2 and 4 in a MyD88-dependent manner [23].”
• The Role of Synovitis in Osteoarthritis pathogenesis (2012, background): “These include matrix components such as tenascin C [72,19], fibronectin isoforms [17,59], small molecular weight species of hyaluronic acid [6,91,105,106] and biglycan [9,23,80,90].”