A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

By Gyorgy Hutvagner, Juanita Mclachlan, A. Pasquinelli, E. Balint, Thomas Tuschl, Phillip D. Zamore. Science, 2001

2,947 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/33da7580803c6e2dc0eb67116fbac7d5a9a2519a

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In Cancer Research

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Citations in the corpus

Discovering microRNAs from deep sequencing data using miRDeep (2008, background): “These are then exported to the cytosol, where the hairpin structure is cut by the endonuclease Dicer at relatively fixed position”
New microRNAs from mouse and human. (2003, background): “Mature miRNAs are ∼ 21 nt long and excised from 60-to 80-nt double-stranded RNA foldbacks (dsRNA hairpins) by Dicer RNase III (Grishok et al. 2001; Hutvágner et al. 2001; Ketting et al. 2001; Park et al. 2002; Reinhart et al. 2002).”
RNA Interference: Biology, Mechanism, and Applications (2003, background): “In fact, both siRNAs and micro-RNAs are processed by Dicer activities in animals as well as in plants (86, 96, 104, 115, 240).”
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (2007, background): “To identify putative target genes of any miRNA, we performed a microarray hybridization of cellular mRNA after small interfering RNA (siRNA)-mediated knockdown of Dicer, an enzyme essential for miRNA biogenesis (Hutvagner et al. 2001).”
High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma (2004, background): “Mature miRNAs are 21–23 nt long and are excised from an approximately 60- to 80-nt double-stranded RNA hairpin by Dicer RNase III (Hutvagner et al., 2001).”
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. (2002, methodology): “In a subsequent report (25), siRNA was used against a human homologue of the RNAi component Dicer to demonstrate its involvement in the maturation of let-7 stRNA, which belongs to a group of short RNAs involved in temporal control of expression through interference with translation (26,27).”
Two classes of short interfering RNA in RNA silencing (2002, neutral): “) $% ' & ' <$ 7( 1 / -88 ; ) ' / -88 ; ' / -88 9/ = & ' % ) ) !”