The Trojan exosome hypothesis

By S. Gould, A. Booth, James E. K. Hildreth. Proceedings of the National Academy of Sciences of the United States of America, 2003

619 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/33af7010d79a1bd9f7face186ec6e137a7efdf4d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

In Virology

Citations in the corpus

Exosomes: endosomal-derived vesicles shipping extracellular messages. (2004, result): “a comparative study of exosomes and HIV particles [54], have lead to the ‘Trojan exosome’ hypothesis [55], which suggests that enveloped viruses have evolved to exploit the MVB pathway to generate virus particles.”
The protein network of HIV budding. (2003, background): “AIP11–716 lacked is given in Gould et al. (2003). the proline-rich region, which hindered expression of full-length AIP1.”
Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “…exosomes have many similarities, including lipid composition and the presence of host-cell proteins, retroviruses have been proposed to have hijacked the pathway of exosome biogenesis for their production to escape from immune detection (i.e., the Trojan exosome hypothesis) (Gould et al., 2003).”
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis (2011, background): “The same holds true for the cytomegalovirus and retrovirus (Booth et al., 2006; Gould et al., 2003; Walker et al., 2009).”
RNA regulons: coordination of post-transcriptional events (2007, background): “The function of exosomes in protein exchange among cells is well established, and the 'Trojan exosome hypothesis' proposes that retroviruses can use exosomes for the transmission of retroviral particle”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, positive): “Some of these mechanisms are similar to those described for extracellular budding of virus particles, such as retroviruses (Gould et al. 2003), and, in fact, a substantial portion of EVs released from cancer cells are retrovirus-like particles (Akers et al. 2013; Balaj et al. 2011).”
Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “Interestingly, recent studies in HIV-1-infected macrophages have suggested that HIV-1 is present within internally seques- tered CD63-positive plasma membrane domains but not in endosomes (65).”