Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

By M. Liao, Yang Liu, Jing Yuan, Yanling Wen, Gang Xu, Juanjuan Zhao, Jin-xiu Li, Xin Wang, Fuxiang Wang, Lei Liu and 3 more. Nature Medicine, 2020

2,345 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/332c89202a3332bfcc63a3641a6327426fc39c3b

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Citations in the corpus

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 (2020, positive): “Also, tissue damage induced by SARS-CoV-2 infectionmay lead to releaseof pathogen- anddamage-associated molecular patterns that, in turn, induce activation and recruitment of inflammatory cytokine- and chemokine-producing innate immunecells in anamplifying loop (Liao et al., 2020).”
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020, background): “Evidence supporting a role for T cells in COVID-19 protection and pathogenesis is currently incomplete and sometimes conflicting[3, 11, 12, 13, 14].”
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity (2020, positive): “Additionally, while immunological data from lungs of COVID-19 cases are limited, the data on total abundance of CD8 + T cells in COVID-19 lungs (Liao et al., 2020) are consistent with our conclusion that weaker SARS-CoV-2-speciﬁc T cell responses are associated with worse disease.”
scCODA is a Bayesian model for compositional single-cell data analysis (2021, background): “Although being important drivers of biological processes such as in disease 1 , development 2 , aging 3 , and immunity 4 , shifts in cell-type compositions are non-trivial to detect using scRNA-seq.”
Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, positive): “In contrast, end-stage disease is not generally associated with preferentially elevated T cell abundance in lung tissue (Liao et al., 2020; Oja et al., 2020; Szabo et al., 2020), consistent with a working model that early adaptive immune responses are very beneficial, and late adaptive immune respon”
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches (2022, positive): “Indeed, this would be consistent with the presence of LAM-like cells in multiple tissues including the obese adipose tissue, the brain, the lung, and the heart (Jaitin et al., 2019; Keren-Shaul et al., 2017; Liao et al., 2020; Rizzo et al., 2020).”
COVID-19 and the human innate immune system (2021, background): “ISG, interferon response gene; Mac, macrophage; mDC, myeloid dendritic cell; NKG2A, NK cell receptor (CD159a) encoded by killer cell lectin lectin-like receptor C1, KLRC1; pDC, plasmacytoid dendritic cell; SPP1, secreted phosphoprotein 1 (coding for osteopontin); TGF-B2, transforming growth factor b”