Corneal avascularity is due to soluble VEGF receptor-1
By M. Nozaki, B. Raisler, J. Baffi, A. Takeda, J. Witta, Sandro Defalco, M. Shibuya, B. Ambati, J. Ambati. Nature, 2006
707 citations recorded by the source corpus.
Subfields: Control and Systems Engineering, Discrete Mathematics and Combinatorics
View Paper: https://www.semanticscholar.org/paper/3320058ce8da8fbff247b00434a31101654f6b8f
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Citations in the corpus
- ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. (2010, background): “Corneal neovascularization, which appears to occur spontaneously in ADAMTS9 / mice in the C57Bl/6 strain, is unusual since avascularity of the cornea is normally ensured by intrinsic anti-angiogenic factors.(43) The inability of these intrinsic mechanisms to stave off invading ADAMTS9 haploinsuffici”
- Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. (2011, background): “sFlt-1 was also found to be expressed in corneal epithelial cells.(50) This strongly suggests that sFlt-1 suppresses angiogenesis near the lens and maintains the transparency of the eye.”
- Ten years of anti-vascular endothelial growth factor therapy (2016, background): “An alternatively spliced, soluble form of VEGFR1 that is expressed in a variety of other tissues has been implicated as a negative regulator of angiogenesis in the eye 43 .”
- Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. (2018, background): “Its presence in the corneal epithelium explains the absence of corneal vascularization [26, 35, 37].”
- Signal transduction by vascular endothelial growth factor receptors. (2012, background): “Consequently, sFlt1 has been implicated as a negative regulator of angiogenesis (e.g., in maintenance of corneal avascularity [Ambati et al. 2006]).”
- Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. (2013, background): “(37) reported that sFlt-1 is expressed in the eye to maintain avascularity in the cornea.”