Polycomb complexes repress developmental regulators in murine embryonic stem cells
By Laurie A. Boyer, Kathrin Plath, J. Zeitlinger, T. Brambrink, Lea A. Medeiros, Tong Ihn Lee, S. Levine, Marius Wernig, Adriana Tajonar, Mridula K. Ray and 6 more. Nature, 2006
2,693 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/32f0874c3cefaadf189b0cb6e2c28544b531ce9d
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In Molecular Biology
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Citations in the corpus
- An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “In parallel, other work has suggested that histone modification signatures, specifically histone 3 lysine 4 and histone 3 lysine 27 trimethylation (H3K4me3 and H3K27me3, respectively), are important in controlling gene regulation in ES cells (Bernstein et al., 2006; Boyer et al., 2006; Lee et al., 2”
- Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “…of pluripotent mouse and human embryonic stem cells (ESCs) have shown that PRC2 proteins and their triMeK27-H3 marks reside at and transcriptionally repress many regulatory genes that control specific developmental lineages (Boyer et al., 2006; Lee et al., 2006; Pietersen and van Lohuizen, 2008).”
- A double take on bivalent promoters. (2013, background): “Interestingly, when analyzing the genomic localization of components of the PRC2 complex, defined peaks are predominantly found around gene promoters (Boyer et al. 2006; Bracken et al. 2006; Ku et al. 2008), indicating more efficient recruitment or retention at promoters.”
- The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. (2010, background): “The PcG protein EZH2 is a histone methyltransferase specific to H3K27 trimethylation, and PcGs are known to play key roles in stem cell pluripotency (Bernstein et al. 2006; Boyer et al. 2006).”
- Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. (2007, background): “Among PcG proteins, PRC2 is of particular importance since it has been linked to stem cell biology and cancer (Kleer et al. 2003; Gil et al. 2005; Bernstein et al. 2006; Boyer et al. 2006; Bracken et al. 2006; Holden 2006; Kalantry et al. 2006; Kamminga et al. 2006; Lee et al. 2006).”
- Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “…neuron are highly enriched for genes involved in neuronal development, ion transport, and neurotransmitter regulation (Group 1 in Figures 4B and 4C and Table S1), in line with previous findings that many neuronal genes are targeted by Polycomb in ESCs (Boyer et al., 2006; Pan et al., 2007).”