Whole-Genome Patterns of Common DNA Variation in Three Human Populations

By David A. Hinds, L. Stuve, Geoffrey B. Nilsen, Eran Halperin, Eleazar Eskin, D. Ballinger, Kelly A. Frazer, D. Cox. Science, 2005

1,211 citations recorded by the source corpus.

Subfields: Genetics

View Paper: https://www.semanticscholar.org/paper/32bd4ae5e6d9d8edd447caddfaacef99ffeb15b3

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In Genetics

Citations in the corpus

A Draft Sequence of the Neandertal Genome (2010, positive): “We used 1,263,750 Perlegen Class A SNPs, identified in individuals of diverse ancestry (78), and found 13 candidate regions of Neandertal ancestry (SOM Text 17).”
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. (2007, methodology): “We then chose tag SNPs for all European-American LD bins (38) crossing the exons of the candidate genes, with two SNPs for each bin with three or more SNPs.”
Copy number variation: new insights in genome diversity. (2006, methodology): “The deletions were then typed in a sample of 71 individuals who had previously been genotyped for ∼1.6 million genome-wide SNPs (Hinds et al. 2005), enabling comparison of the two data sets.”
Ensembl variation resources (2010, methodology): “For example, in release 56 Ensembl has genotype data for 8335 individuals from a number of reference data sets including the HapMap [25], Perlegen [26] and the 1000 Genomes Project [2].”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “Since then, the number of SNPs in the public databases has been rising and currently more than 10 million validated SNPs are available (Hinds et al. 2005).”
Whole genome genotyping technologies on the BeadArray™ platform (2007, methodology): “Based on recent HapMap data, the key technology needs for genome-wide association studies are: (i) the ability to accurately and economically genotype hundreds of thousands of loci across thousands of well-phenotyped case and matched-control population samples [6, 7], (ii) a robust means of processi”
New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree. (2008, background): “Because haplogroups R-M269, E-P1, and I-P30 are found at relatively high frequency in the European and African populations used in the ascertainment process (Hinds et al. 2005), we expect the number of SNPs discovered on these lineages to be fairly representative of the relative length of these bran”