Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
By Scott F. Saccone, Anthony L. Hinrichs, N. Saccone, G. Chase, Karel Konvička, P. Madden, N. Breslau, Eric O. Johnson, D. Hatsukami, O. Pomerleau and 12 more. Human Molecular Genetics, 2007
871 citations recorded by the source corpus.
Subfields: Molecular Biology, Organic Chemistry, Physiology
View Paper: https://www.semanticscholar.org/paper/b6156bd783a121439b750e301f3cfa97d746e60c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- A. Valdes
- Tim D. Spector
- Dorret I. Boomsma
- Gordon B. Mills
- Mark I. McCarthy
- Yurii S. Aulchenko
- N. Benowitz
- David B. Goldstein
In Organic Chemistry
In Physiology
Citations in the corpus
- Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior (2010, background): “Among the genes at the two newly associated loci are genes encoding nicotine-metabolizing enzymes ( CYP2A6 and CYP2B6 ) and nicotinic acetylcholine receptor subunits ( CHRNB3 and CHRNA6 ), all of which have been highlighted in previous studies of smoking and nicotine dependenc”
- Variants in nicotinic receptors and risk for nicotine dependence. (2008, methodology): “These findings confirm our previous results in a case-control series studying nicotine dependence (6) and the recent work by Berrettini et al.”
- Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 (2008, background): “Because CHRNA3 and CHRNA5 may have a role in nicotine dependenc”
- A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci (2009, result): “Association of this locus with nicotine dependence has been reported in two other studies [15,16].”
- Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics (2009, background): “Bierut, Saccone, and coworkers examined a phenotype that is thought to reflect a vulnerability to becoming dependent on nicotine (48, 49).”
- Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function (2009, background): “also implicated the HHIP region along with CHRNA3-CHRNA5 on chromosome 15, a region previously associated with nicotine dependenc”
- Detection of sharing by descent, long-range phasing and haplotype imputation (2008, background): “Here we focus on a region around the nicotinic acetylcholine receptor gene cluster ( CHRNA5 , CHRNA3 and CHRNB4 ) on 15q25 where variants, including allele T of SNP rs1051730, were recently shown to associate with smoking behavior, lung cancer and peripheral arterial diseas”