Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution.

By F. Heller, P. Florian, C. Bojarski, J. Richter, M. Christ, Bernd Hillenbrand, J. Mankertz, A. Gitter, N. Bürgel, M. Fromm and 4 more. Gastroenterology, 2005

1,205 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/32a5a90b4c81068f570c703e6baac80a5ddfad1e

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In Genetics

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In Molecular Biology

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In Neurology

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Citations in the corpus

• Intestinal mucosal barrier function in health and disease (2009, background): “Expression of specific claudin proteins changes during development, differentiation and disease and in response to stressors — including cytokines — in intestina”
• Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “As briefly described above and reviewed in detail elsewhere (43), the claudin residues responsible for ion selectivity and modulation of pore pathway permeability by changes in claudin protein expression have been well documented in cell culture (34, 37, 38, 40, 137–141), animal models (16, 32), and”
• Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis (2008, background): “Finally, the presence of a large number of stressed cells within the intestinal epithelium and the production of IL-1b, TNF-a, and IL-13, are likely to attenuate epithelial tight junction integrity, leading to the impaired epithelial barrier function we demonstrate [52,56].”
• Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development (2020, background): “Increased immune activation of the epithelial cells leads to the increased production of TNFα and IL-13, which increase paracellular transport by interfering with the expression and/or organization of proteins within the tight junctions [88, 89].”
• Tight junctions and the modulation of barrier function in disease (2008, background): “for the nature of these pro-inXammatory mediators eVecting the TJ disruption and dysfunction, investigators (Conyers et al. 1990; Heller et al. 2005; Prasad et al. 2005) had identiWed IL-13, IFN and TNF as factors in patient’s serum lowering resistance and opening TJs.”
• Innate and adaptive immunity in inflammatory bowel disease. (2014, background): “Gastroenterology [62]”