Mass Spectrometry and Protein Analysis

By B. Domon, R. Aebersold. Science, 2006

2,057 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/327c6417e69319de13e41aa24892aa6f49320ed5

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Citations in the corpus

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer (2018, positive): “Time-of-flight (TOF) instruments have several very desirable properties for the analysis of complex peptide mixtures and have consequently been employed in shotgun proteomics for a long time (8, 9).”
Analysis and validation of proteomic data generated by tandem mass spectrometry (2007, background): “At present, the vast majority of proteomic data are being generated by mass spectrometry, more specifically by tandem mass spectrometers of ever increasing performanc”
PeptideAtlas: a resource for target selection for emerging targeted proteomics workflows (2008, methodology): “…a quantitative measurement for each desired peptide and protein. the instrumental aspect of targeted proteomics has been reviewed previously (Domon & aebersold, 2006; Kuster et al , 2005). the other requirement of a targeted proteomics workflow is a method to compile the list of target…”
Correlation of mRNA and protein in complex biological samples (2009, neutral): “Several mass spectrometer designs exist, each with speciﬁc advantages for mass accuracy, dynamic range, resolving power and sensitivity [22].”
Toward single-molecule nanomechanical mass spectrometry (2005, background): “This enhanced sensitivity of NEMS is opening a variety of unprecedented opportunities for applications such as mass spectrometry, which is now widely used for proteomic”
Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis* (2012, methodology): “For this method, the MS instrument is operated in data-dependent acquisition (DDA) mode, where fragment ion (MS2) spectra for selected precursor ions detectable in a survey (MS1) scan are generated (5).”
Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer (2011, background): “Because tens of thousands of peptides elute over a relatively short time and with ion signals different by many orders of magnitude (4, 5), mass spectrometers have been pushed to even higher sensitivity, sequencing speed, and resolution (6, 7).”