Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.

By Xiaoyan M. Zhang, M. Ramalho-Santos, Andrew P. McMahon. Cell, 2001

618 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/322b2f53c2110af9041a380266b9c187ec05cb0b

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Citations in the corpus

Forkhead transcription factors: key players in development and metabolism. (2002, background): “Left–right asymmetry in the vertebrate embryo is initiated in the node and requires hedgehog signaling (Levin et al., 1995; Zhang et al., 2001).”
The graded response to Sonic Hedgehog depends on cilia architecture. (2007, background): “Smo mutants lack both Shh and Ihh signaling and have a slightly stronger effect on neural patterning than Shh mutants (Caspary et al., 2002; Zhang et al., 2001).”
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network (2008, background): “In ventral regions of the presumptive spinal cord, the secreted molecule sonic hedgehog (Shh) acts as a long-range morphogen (Box 1) that directs the pattern of neurogenesis by conferring positional information to ventral neural progenitors (see Jessell, 2000; Lupo et al., 2006).”
Hedgehog signaling in animal development: paradigms and principles. (2001, background): “…only be understood in the context of a third protein, Smoothened (Smo), the activity of which appears to be essential for all aspects of Hh signaling both in Drosophila (Alcedo et al. 1996; Chen and Struhl 1996; van den Heuvel and Ingham 1996) and vertebrates (Chen et al. 2001; Zhang et al. 2001).”
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. (2003, neutral): “A constitutively null allele of Smo (Smonull) has also been described (Zhang et al., 2001).”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “Hh signaling in mammals relies on the transmembrane protein Smoothened (Smo) (Zhang et al., 2001).”
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis (2005, background): “For example, in the mouse, IFT proteins have been implicated in hedgehog signaling (Huangfu et al., 2003), and hedgehog signaling has been implicated in left-right patterning (Zhang et al., 2001).”
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. (2004, background): “S1B; Zhang et al. 2001; Wnt1-Cre;Smon/c).”
Depletion of definitive gut endoderm in Sox17-null mutant mice. (2002, background): “However, a more widespread deficiency in Hh signalling in the Shh/Ihh-double mutant embryo has also resulted in a similar developmental arrest phenotype with the lack of axis rotation at the early somite stage (Zhang et al., 2001).”
Hedgehog: functions and mechanisms. (2008, background): “References: the role of Hh in early embryogenesis prior to TS 15 (Chiang et al. 1996; Zhang et al. 2001; Astorga and Carlsson 2007); limb development (Ahn and Joyner 2004); cranial neural crest (Jeong et al.”
Building muscle: molecular regulation of myogenesis. (2012, background): “Shh or smoothened knockout mice display an impaired formation of the sclerotome as well as reduced expression of Myf5 in the myotome (Chiang et al. 1996; Zhang et al. 2001).”