Shunting inhibition modulates neuronal gain during synaptic excitation.

By Simon J. Mitchell, R. Silver. 2003

650 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “, 2015), in part by matching spike threshold to the overall activity level (Mitchell and Silver, 2003; Billings et al. 2014; Tabuchi et al., 2018).”
Dopamine and Cognitive Control in Prefrontal Cortex. (2019, background): “Such a response modulation may improve the ability of cortical networks to detect sensory events [77], causing an adaptive rescaling of its input so as to maximize information transmission [78,79].”
Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene (2006, background): “Small changes in tonic current are known to have profound effects on the excitability of granule cells (Hamann et al., 2002; Mitchell and Silver, 2003; Chadderton et al., 2004).”
Dendritic excitability and synaptic plasticity. (2008, positive): “Changes in the statistics of noisy synaptic inputs and changes in the ratio of excitation to inhibition can change the slope of the f/I curve and thus the gain of the neuron (120, 528, 611).”
NMDA receptors with incomplete Mg2+ block enable low-frequency transmission through the cerebellar cortex (2012, background): “, 2002) and inhibition (Mitchell and Silver, 2003) also influReceived Nov.”
Pathway-Specific Drive of Cerebellar Golgi Cells Reveals Integrative Rules of Cortical Inhibition (2018, background): “410 GoC recruitment scales with MF input density 411 The dynamic clamp experiments indicate that fast phasic feedforward inhibition from GoCs 412 plays only a minor role in temporally structuring GrC responses to MF input and support the 413 alternative view that slow, convergent inhibitory events p”
Purkinje cells directly inhibit granule cells in specialized regions of the cerebellar cortex (2016, positive): “Functional Roles of PC to GrC Inhibition Previous studies established that fast and slow GoC to GrC inhibition and tonic inhibition reduce GrC excitability (Crowley et al., 2009; Mitchell and Silver, 2003; Rothman et al., 2009).”
Synaptic and cellular properties of the feed-forward inhibitory circuit within the input layer of the cerebellar cortex (2008, background): “This, together with the wide dynamic range and non-accommodating nature of GrCs firing, promotes the efficient transmission of rate-coded information from MFs to GrCs (Mitchell and Silver, 2003).”
Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input (2010, positive): “Nevertheless, variations in inhibitory input synchrony may be a dynamic way to alter granule cell gain during sensory input, in addition to the steady-state tonic inhibitory component (Crowley et al., 2009; Mitchell and Silver, 2003; Rothman et al., 2009).”
How Inhibition Shapes Cortical Activity (2011, positive): “This slope is not fixed but can be modulated, a phenomenon that goes under the name of gain control (Carvalho and Buonomano, 2009; Chance et al., 2002; Mitchell and Silver, 2003; Shu et al., 2003).”
Tonically active GABA A receptors: modulating gain and maintaining the tone. (2004, background): “Modelling predicts that the mathematical operations performed by tonic inhibition depend on the variability of the excitatory rate-coded input [ 41 ].”