Synaptic and cellular properties of the feed-forward inhibitory circuit within the input layer of the cerebellar cortex
By Kanichay Rt, Silver Ra. 2008
137 citations recorded by the source corpus.
Precise representation of the timing of sensory stimuli is essential for rapid motor coordination, a core function of the cerebellum. Feedforward inhibition has been implicated in precise temporal signaling in several regions of the brain, but little is known about this type of inhibitory circuit within the input layer of the cerebellar cortex. We investigated the synaptic properties of feedforward inhibition at near physiological temperatures (35°C) in rat cerebellar slices. We establish that the previously uncharacterized mossy fiber–Golgi cell–granule cell pathway can act as a functional feedforward inhibitory circuit. The synchronous activation of four mossy fibers, releasing a total of six quanta onto a Golgi cell, can reset spontaneous Golgi cell firing with high temporal precision (200 μs). However, only modest increases in Golgi cell firing rate were observed during trains of high-frequency mossy fiber stimulation. This decoupling of Golgi cell activity from mossy fiber firing rate was attributable to a strong afterhyperpolarization after each action potential, preventing mossy fiber–Golgi cell signaling for ∼50 ms. Feedforward excitation of Golgi cells induced a temporally precise inhibitory conductance in granule cells that curtailed the excitatory action of the mossy fiber EPSC. The synaptic and cellular properties of this feedforward circuit appear tuned to trigger a fast inhibitory conductance in granule cells at the onset of stimuli that produce intense bursts of activity in multiple mossy fibers, thereby conserving the temporal precision of the initial granule cell response.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology
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Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “…from Golgi cells (Vos et al., 1999; Duguid et al., 2015), which are driven by excitatory inputs from mossy fibres through their basal dendrites (Kanichay and Silver, 2008) and ascending granule cell axons and parallel fibres through their apical dendrites (Dieudonné, 1998; Cesana et al., 2013).”
- Are mushroom bodies cerebellum-like structures? (2011, background): “…glomeruli, which also contain the terminals of GABAergic neurons (called Golgi cells in cerebellum) providing feedback and feedforward inhibition to granule cells (Ito, 2006; BalakrishnanandTrussell, 2008; Kanichay and Silver, 2008; Shi et al., 2008; Arenz et al., 2009; D’Angelo andDeZeeuw, 2009).”
- Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding (2014, background): “Golgi cells provide network-activity-dependent inhibition of GCs, via feedforward (Kanichay and Silver, 2008) and feedback inhibition (Cesana et al., 2013), although the impact of this phasic and spillover-mediated component is much weaker than tonic inhibition (Duguid et al., 2012).”
- Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input (2010, unknown): “Moreover, GoCs are sparsely innervated by excitatory mossy fiber (MF) synapses, which can be selectively activated in acute slices (Kanichay and Silver, 2008).”
- A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity (2015, unknown): “Modulation of spike frequency and timing in the CN projection neurons is considered to be mostly determined by the massive inhibitory cortico-nuclear projection of PNs (Chan-Palay, 1977; De Zeeuw and Berrebi, 1995; Gauck and Jaeger, 2000; Telgkamp and Raman, 2002; Pedroarena and Schwarz, 2003; Telgk”
- Pathway-Specific Drive of Cerebellar Golgi Cells Reveals Integrative Rules of Cortical Inhibition (2018, unknown): “Another source of complexity in relating MF activity to recruitment of feedforward inhibition is the fact that EPSP-spike coupling in GoCs is heavily temporally filtered (Vervaeke et al., 2010; Kanichay and Silver, 2008).”
- Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity (2012, unknown): “Slices were cut in an ice-cold solution (Dugué et al., 2005; Forti et al., 2006; Kanichay and Silver, 2008) consisting of 130 mM K-gluconate, 15 mM KCl, 0.”