Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia.

By H. H. Marti, M. Bernaudin, A. Bellail, Heike J. Schoch, M. Euler, E. Petit, W. Risau. American Journal of Pathology, 2000

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HIF-1 and human disease: one highly involved factor. (2000, background): “Colocalization of HIF-1 and VEGF expression has also been demonstrated in the penumbra and is associated with neovascularization (Marti et al. 2000).”
Cerebral Microvessel Responses to Focal Ischemia (2003, background): “The group of Risau has demonstrated that hypoxiainduced VEGF expression precedes neovascularization in the border zone of the ischemic neocortex in the rodent (Marti et al., 2000).”
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression (2005, background): “…it is known that both glial as well as neuronal expression are strongly upregulated throughout the adult brain (Shweiki et al., 1992; Xu & Severinghaus, 1998; Issa et al., 1999; Kuo et al., 1999; Ogunshola et al., 2000), including the hippocampal DG (Marti & Risau, 1998; Marti et al., 2000).”