Antigenicity and immunogenicity of collagen.

By A. Lynn, I. Yannas, W. Bonfield. Journal of Biomedical Materials Research. Part B - Applied biomaterials, 2004

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Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. (2007, positive): “However, purification techniques using enzymatic treatments may be employed to eliminate the immunogenic telopeptides, the major cause of foreign body response [16,17], as well as the development of recombinant and nonrecombinant human collagens as a replacement for animal tissue-derived material.”
Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives (2016, background): “The cross-link formation can shield or modify major antigenic sites and, thus, reduce their capacity to interact with antibodies [22].”
Collagen-hydroxyapatite composites for hard tissue repair. (2006, background): “Furthermore, the literature has yet to find any significant evidence on human immunological benefits of deficient-telopeptide collagens (Lynn et al., 2004).”