Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications.
By P. Malafaya, G. A. Silva, Rui Luís Reis. Advanced Drug Delivery Reviews, 2007
1,348 citations recorded by the source corpus.
The present paper intends to overview a wide range of natural-origin polymers with special focus on proteins and polysaccharides (the systems more inspired on the extracellular matrix) that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues. The combination of both applications into a single material has proven to be very challenging though. The paper presents also some examples of commercially available natural-origin polymers with applications in research or in clinical use in several applications. As it is recognized, this class of polymers is being widely used due to their similarities with the extracellular matrix, high chemical versatility, typically good biological performance and inherent cellular interaction and, also very significant, the cell or enzyme-controlled degradability. These biocharacteristics classify the natural-origin polymers as one of the most attractive options to be used in the tissue engineering field and drug delivery applications.
Subfields: Biomaterials, Biomedical Engineering
View Paper: https://www.semanticscholar.org/paper/f83a6dcd87732bb6c2f84694e79c56c5c8bbfa5b
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In Biomedical Engineering
Citations in the corpus
- Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration (2010, background): “Apart from chitosan, which is highly positively charged, all of the other proteins mentioned above preserve a large number of negatively charged groups [65].”
- Controlled drug delivery in tissue engineering. (2008, neutral): “Furthermore, by combining material chemistry and processing technology, scaffold degradation rate can be tuned to match the rate of tissue growth in such a way that the regenerated tissue may progressively replace the scaffold [14–16].”
- Macroalgal biorefinery concepts for the circular bioeconomy: A review on biotechnological developments and future perspectives (2021, background): “In particular, macroalgal polysaccharides have shown promise in cartilage tissue engineering applications [163] and cartilage repair [164], due to their structural and chemical similarity with native tissue components, non-harsh processing, and variable degrees of hydrophilicity and bio-compatibilit”