Collagen-hydroxyapatite composites for hard tissue repair.
By D. Wahl, J. Czernuszka. European Cells & Materials, 2006
643 citations recorded by the source corpus.
Bone is the most implanted tissue after blood. The major solid components of human bone are collagen (a natural polymer, also found in skin and tendons) and a substituted hydroxyapatite (a natural ceramic, also found in teeth). Although these two components when used separately provide a relatively successful mean of augmenting bone growth, the composite of the two natural materials exceeds this success. This paper provides a review of the most common routes to the fabrication of collagen (Col) and hydroxyapatite (HA) composites for bone analogues. The regeneration of diseased or fractured bones is the challenge faced by current technologies in tissue engineering. Hydroxyapatite and collagen composites (Col-HA) have the potential in mimicking and replacing skeletal bones. Both in vivo and in vitro studies show the importance of collagen type, mineralisation conditions, porosity, manufacturing conditions and crosslinking. The results outlined on mechanical properties, cell culturing and de-novo bone growth of these devices relate to the efficiency of these to be used as future bone implants. Solid free form fabrication where a mould can be built up layer by layer, providing shape and internal vascularisation may provide an improved method of creating composite structures.
Subfields: Biomedical Engineering, Oral Surgery, Urology
View Paper: https://www.semanticscholar.org/paper/a28d041387c977f9fa4ce9e8e747b89f63e97a5c
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In Biomedical Engineering
In Oral Surgery
In Urology
Citations in the corpus
- Bone substitutes in orthopaedic surgery: from basic science to clinical practice (2014, background): “In summary therefore, combining both collagen and hydroxyapatite should provide an advantage over other materials for use in bone tissue repair [85].”
- Nanoscale hydroxyapatite particles for bone tissue engineering. (2011, neutral): “in a series of studies [131–133].”
- Calcium Orthophosphates in Nature, Biology and Medicine (2009, background): “There is still no clear idea why the crystals of biological apatite are platelet-shaped even though dahllite has hexagonal crystal symmetry [311,362,371-375,381-386,388-391].”
- Current Perspectives (2013, background): “In other words, the ductile properties of collagen compensate for the poor fracture toughness of calcium phosphate (Fan et al., 2005; Wahl and Czernuszka, 2006; Otsuka et al., 2010).”