Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

By C. Janus, J. Pearson, J. McLaurin, P. Mathews, Ying Jiang, S. Schmidt, M. Chishti, P. Horne, D. Heslin, J. French and 7 more. Nature, 2000

1,381 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/30a3fe16ab85692e478e2698972a4cfb5d342f9c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. G. Shankar
2. Martin Citron
3. D. Selkoe
4. Rudolph E. Tanzi
5. John Hardy
6. P. Reddy

In Pharmacology

1. Martin Citron
2. Bradley T. Hyman
3. K. Ono
4. Rudolph E. Tanzi
5. D. Selkoe
6. David Watson
7. L. Mucke
8. George Bartzokis

In Physiology

1. D. Selkoe
2. John Hardy
3. Bradley T. Hyman
4. G. Shankar
5. Martin Citron
6. Nina E. Shepardson
7. Shaomin Li
8. K. Ono

Citations in the corpus

• Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro (2004, background): “Vaccination (Schenk et al., 1999; Janus et al., 2000; Morgan et al., 2000) and secretase inhibitors (Skovronsky et al., 2000) have been reported as experimental therapies and for clinical trials.”
• The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal (2009, background): “…this immediately ameliorated the subtle behavioral alterations in transgenic APP animals was interpreted as indicating that this prediction had been fulfilled in animals (Janus et al. 2000; Morgan et al. 2000; Dodart et al. 2002), but as indicated above, perhaps this interpretation was premature.”
• Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease (2005, result): “This reduction was present in both cortical and hippocampal regions of the brain after long-term exercise and was comparable with the effects seen with interventions such as A! immunization, which resulted in a 50% reduction in A! in this same transgenic line (Janus et al., 2000).”
• Alzheimer's disease: strategies for disease modification (2010, background): “The reduction in amyloid pathology was subsequently reproduced in several studies using different transgenic mouse model”
• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options (2009, background): “A promising example is Amyloid- vaccination in AD that prevents plaque formation and subsequent neuron inflammation [43].”