Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

By F. Sacks, G. Bray, V. Carey, Steven R Smith, D. Ryan, S. Anton, K. McManus, C. Champagne, Louise M. Bishop, N. Laranjo and 7 more. New England Journal of Medicine, 2009

1,995 citations recorded by the source corpus.

BACKGROUND The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year. METHODS We randomly assigned 811 overweight adults to one of four diets; the targeted percentages of energy derived from fat, protein, and carbohydrates in the four diets were 20, 15, and 65%; 20, 25, and 55%; 40, 15, and 45%; and 40, 25, and 35%. The diets consisted of similar foods and met guidelines for cardiovascular health. The participants were offered group and individual instructional sessions for 2 years. The primary outcome was the change in body weight after 2 years in two-by-two factorial comparisons of low fat versus high fat and average protein versus high protein and in the comparison of highest and lowest carbohydrate content. RESULTS At 6 months, participants assigned to each diet had lost an average of 6 kg, which represented 7% of their initial weight; they began to regain weight after 12 months. By 2 years, weight loss remained similar in those who were assigned to a diet with 15% protein and those assigned to a diet with 25% protein (3.0 and 3.6 kg, respectively); in those assigned to a diet with 20% fat and those assigned to a diet with 40% fat (3.3 kg for both groups); and in those assigned to a diet with 65% carbohydrates and those assigned to a diet with 35% carbohydrates (2.9 and 3.4 kg, respectively) (P>0.20 for all comparisons). Among the 80% of participants who completed the trial, the average weight loss was 4 kg; 14 to 15% of the participants had a reduction of at least 10% of their initial body weight. Satiety, hunger, satisfaction with the diet, and attendance at group sessions were similar for all diets; attendance was strongly associated with weight loss (0.2 kg per session attended). The diets improved lipid-related risk factors and fasting insulin levels. CONCLUSIONS Reduced-calorie diets result in clinically meaningful weight loss regardless of which macronutrients they emphasize.

Subfields: Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/309c2f42a5b6ca3290f9030dc0c7231c9601786d

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In Nutrition and Dietetics

1. Jianping Ye
2. F. B. Hu
3. S. Grundy
4. A. Hruby
5. W. Willett
6. D. Mozaffarian
7. G. Hoffmann
8. L. Schwingshackl

In Physiology

1. Jianping Ye
2. M. Sevick
3. Lora E. Burke
4. A. Hruby
5. R. Wing
6. F. B. Hu
7. G. Bray
8. W. Cefalu

Citations in the corpus

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• Long Term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals with Type 2 Diabetes: Four Year Results of the Look AHEAD Trial (2010, result): “Based on studies with nondiabetic subjects, the long-term effects of the lifestyle intervention in the Look AHEAD trial are consistent with or greater than those reported previously in other randomized trials with 2- to 3-year follow-up periods or in meta-analyses for blood pressure(15,38,39) and tr”
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