Modulation of microRNA processing by p53

By Hiroshi I. Suzuki, K. Yamagata, K. Sugimoto, T. Iwamoto, S. Kato, K. Miyazono. Nature, 2009

1,208 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/306cf237dd72ef3a728c11d106d3195112d8d1f8

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Citations in the corpus

microRNA regulation of inflammatory responses. (2012, background): “Among these, p53 and Smad are activated during inflammatory responses, suggesting that they impact miRNA biogenesis in selective settings (17, 18).”
MicroRNA control of signal transduction (2010, background): “During DNA damage, p53 binds to the Drosha complex and promotes the post-transcriptional maturation of many miRNAs to pre-miRN”
microRNAs in cancer (2013, background): “Doxorubicin induction of p53 increases the expression of several mature miRNAs, such as miR-15, miR16, and miR-145, that have growth-suppressive functions and are downregulated in cancer (98).”
Genetic variation in microRNA networks: the implications for cancer research (2010, positive): “The tumour suppressor p53 was recently implicated in miRNA processin”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “In addition, the tumour suppressor protein p53 has an important role in miRNA processing following the onset of DNA damag”
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. (2011, background): “processing is enhanced in the presence of the p53 transcription factor (41).”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “The tumour suppressor p53, for example, interacts with DDX5 to enhance processing of miRNAs that function in growth suppressio”
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, background): “, as well as by distinct chromatin organization and epigenetic signatures that govern their intrinsic ability to self-renew and differentiate into multiple lineage”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “The tumor suppressor protein p53, under conditions of DNA damage, is present in a complex with both Drosha and p68, and enhances Drosha processing of a subset of miRNAs, including miR-16-1 and miR-143 (Suzuki et al., 2009).”
MicroRNAs in human cancer. (2013, background): “Specifically, the DDX5-mediated interaction of the RNASEN complex with the tumor suppressor TP53 was shown to have a stimulatory effect on the tumor suppressor pri-miR-16-1, pri-miR-143 and pri-miR-145 processing in response to DNA damage in cancer cells [101].”