Targeting mitochondria metabolism for cancer therapy

By S. Weinberg, Navdeep S. Chandel. Nature Chemical Biology, 2015

1,222 citations recorded by the source corpus.

Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3054df9fd6dddc4d7d5f28a217a422ce111fcfdd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Ralph J. Deberardinis
2. Navdeep S. Chandel
3. C. V. Dang
4. Huafeng Zhang
5. Alec C. Kimmelman
6. E. White
7. Zhaoyong Li
8. B. Altman

In Molecular Biology

1. Navdeep S. Chandel
2. Ralph J. Deberardinis
3. C. V. Dang
4. Huafeng Zhang
5. Alec C. Kimmelman
6. E. White
7. Zhaoyong Li
8. Lewis C. Cantley

Citations in the corpus

• Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “GLS converts glutamine to glutamate, which is converted into the TCA cycle intermediate a-ketoglutarate by glutamate dehydrogenase or aminotransferases [160].”
• Measuring in vivo mitophagy (2015, background): “Finally, there is a growing interest concerning mitochondria and tumorgenesis (Gaude and Frezza, 2014; Weinberg and Chandel, 2015).”
• Calcium and ROS: A mutual interplay (2015, neutral): “interesting target for tumor therapy [158].”
• Oxidative Phosphorylation as an Emerging Target in Cancer Therapy (2018, background): “This is indeed the case for many cancers, but in some cancers, this assumption is being challenged by an increasing body of evidence to suggest thatmitochondrialmetabolism is not impaired, including leukemias, lymphomas, pancreatic ductal adenocarcinoma, high OXPHOS subtype melanoma, and endometrial”
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH (2015, background): “indicating that the lack of mitochondrial substrates caused by glycolytic inhibition also contributes to ATP depletion in mutant cells (21).”
• Fundamentals of cancer metabolism (2016, background): “Mitochondrial metabolism has also emerged as a key target for cancer therapy, in part, due to the revelation that the antidiabetic drug metformin is an anticancer agent (153).”
• MYC, Metabolism, and Cancer. (2015, background): “In this regard, antiretroviral agents for treatment of HIV, which can inhibit mitochondrial DNA polymerase gamma, may have activity against MYC-driven tumors (179).”
• Autophagy and Tumor Metabolism (2017, background): “Additionally, mitochondrial metabolism has been demonstrated to be critical for ATP production, redox balance, as well as the biosynthesis of other key metabolites in various tumor types (Weinberg and Chandel, 2015).”