The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule

By Stephan Schauder, Kevan M. Shokat, Michael G. Surette, B. Bassler. Molecular Microbiology, 2001

1,049 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3048ebe7ac392003d2913bf6fc3940f345cb5768

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. I. Jahid
2. S. Ha
3. B. Bassler
4. P. Kolenbrander
5. R. Palmer
6. P. Nichols
7. G. Hallegraeff
8. S. Rutherford

In Genetics

1. B. Bassler
2. S. Rutherford
3. S. Ha
4. I. Jahid
5. Christopher M. Waters
6. Klaus Winzer
7. Miguel Cámara
8. R. Palmer

In Molecular Biology

1. B. Bassler
2. S. Rutherford
3. S. Ha
4. I. Jahid
5. Christopher M. Waters
6. Klaus Winzer
7. Miguel Cámara
8. P. Kolenbrander

Citations in the corpus

• Bacterial quorum sensing: its role in virulence and possibilities for its control. (2012, background): “This step is critical for the synthesis of both CAI-1 and AI-2 (Schauder et al. 2001; Wei et al. 2011).”
• Look who's talking: communication and quorum sensing in the bacterial world (2007, background): “In many instances, a role for AI-2 in intra- and interspecies signalling has been proposed (Bassler 1999; Schauder et al. 2001; Federle & Bassler 2003; Henke & Bassler 2004c; Kaper & Sperandio 2005; Xavier & Bassler 2005).”
• Making 'sense' of metabolism: autoinducer-2, LUXS and pathogenic bacteria (2005, background): “The chemical structures first attributed to AI-2 activity were furanone derivatives (particularly 4-HYDROXY-5-METHYL-3(2H)-FURANONE , MHF), by virtue of their ability to induce bioluminescence in the Vibrio harveyi bioassa”
• Bacillus as PGPR in Crop Ecosystem (2011, background): “In Gram-positive bacteria, QS signaling molecules are generally peptides, except for the universal pheromone LuxS found in both Gram-positive and Gramnegative bacteria (Schauder et al. 2001).”
• Exploiting Quorum Sensing To Confuse Bacterial Pathogens (2013, background): “The nucleosidase MTAN (also known as Pfs) catalyzes the removal of adenine from SAH to produce S-ribosyl-L-homocysteine (SRH), and SRH is subsequently converted to homocysteine and DPD by the metalloenzyme LuxS (34).”
• Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “However, in bacteria containing LuxS, two enzymes, Pfs and LuxS, act sequentially to convert SAH to adenine, homocysteine, and the signaling molecule DPD (Figure 8 and Schauder et al. 2001).”
• Bacterial Quorum-Sensing Network Architectures (2009, neutral): “DPD is unstable and spontaneously converts into different moieties in solution (105).”
• Communication among Oral Bacteria (2002, background): “AI-2 is produced from S-adenosylmethionine through several steps, including the required enzymatic conversion of the intermediate S-ribosylhomocysteine by LuxS to 4,5-dihydroxy2,3-pentanedione, which is unstable and is predicted to cyclize spontaneously (133, 134) into a variety of molecules called ”
• Bacterial interactions and successions during plaque development. (2006, background): “(99) proposed that a small molecule called autoinducer-2 was a universal signal mediating messages among the species in mixedspecies communities.”